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Kim, Lee, Han, Kim, Song, Cho, and Lee: APOA5 Polymorphism Is Associated with Metabolic Syndrome in Korean Postmenopausal Women
Original Article
Endocrinology and Metabolism

Endocrinology and Metabolism 2012; 27(4): 276-281.

Published online: 20 December 2012

DOI: https://doi.org/10.3803/EnM.2012.27.4.276

APOA5 Polymorphism Is Associated with Metabolic Syndrome in Korean Postmenopausal Women

Doh Hee Kim, Seung Hee Lee, Kyung Hoon Han, Chae Bong Kim, Kwan Young Song1, Sook Cho2, Kye Heui Lee3

Research Institute, Seoul Medical Center, Seoul, Korea.

1Department of Neurosurgery, Seoul Medical Center, Seoul, Korea.

2Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Korea.

3Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.

Corresponding author: Kye Heui Lee. Department of Internal Medicine, Seoul Medical Center, 156 Sinnae-ro, Jungnang-gu, Seoul 131-865, Korea. Tel: +82-2-2276-7435, Fax: +82-2-2276-8655, people@chol.com

Received 21 May 2012       Accepted 30 October 2012

Copyright © 2012 Korean Endocrine Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Menopause is an independent risk factor in metabolic syndrome which induced an alteration of the lipid metabolism by hormonal changes. Apolipoprotein A5 gene (APOA5) was related to the regulation of triglyceride and high density lipoprotein cholesterol (HDL-C) level with biosynthesis and decomposition. This study was conducted to investigate the relationship between APOA5 polymorphism and metabolic syndrome in Korean postmenopausal women.

Methods

This study included 307 postmenopausal women with anthropometric and biochemical measurement in 2010-2011. The polymorphism of APOA5 was analyzed by polymerase chain reaction-restriction fragment length polymorphism method with MseI restriction enzyme.

Results

The metabolic syndrome prevalence with TT genotype was significantly lower than the frequency in those with TC/CC (27.09%, 38.46%, and 45.71% for TT, TC, and CC, respectively; P < 0.05). Multiple regression analysis of metabolic syndrome risk factors indicated that postmenopausal women with CC genotype had a higher risk with 3 times than that in TT genotype (P < 0.05). APOA5 C carriers showed an increased risk of triglyceride level (odd ratio, 2.93 and 1.85 for CC and TC+CC, respectively; P < 0.05). Interestingly, HDL-C was related to triglyceride directly in comparison to APOA5.

Conclusion

The results of this study indicate that APOA5 has an influence on serum triglyceride and HDL-C, which contribute to metabolic syndrome in Korean postmenopausal women.

Keywords: Apolipoproteins A, HDL cholesterol, Metabolic syndrome X, Single nucleotide polymorphism, Triglycerides

Figures and Tables

Fig. 1
The prevalence of metabolic syndrome according to the APOA5 isoforms. *P < 0.05 by chi-square test. APOA5, apolipoprotein A5; MetS, metabolic syndrome.
enm-27-276-g001
Table 1
Demographic data of study subjects
enm-27-276-i001

Values are expressed as mean ± SD. P value by t test.

BMI, body mass index; DBP, diastolic blood pressure; FBS, fasting blood glucose; HDL-C, high density lipoprotein cholesterol; MetS, metabolic syndrome; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; WC, waist circum- ference.

Table 2
Metabolic syndrome risk factors according to the APOA5 -1131T>C polymorphism
enm-27-276-i002

Values are expressed as mean ± SD. *P < 0.05 by one-way ANOVA test.

APOA5, apolipoprotein A5; BMI, body mass index; DBP, diastolic blood pressure; FBS, fasting blood glucose; HDL-C, high density lipoprotein cholesterol; MetS, meta- bolic syndrome; SBP, systolic blood pressure; TC, total cholesterol; TG, triglyceride; WC, waist circumference.

Table 3
Logistic regression analysis for the association between APOA5 -1131T>C polymorphism and metabolic syndrome after adjusting metabolic syndrome risk factors
enm-27-276-i003

APOA5, apolipoprotein A5; CI, confidence interval; OR, odds ratio.

Table 4
Multiple logistic regression analysis for the association of APOA5 isoforms with high triglyceride and low HDL-C prevalence
enm-27-276-i004

*Adjusted for age; †Adjusted for age, FBS, BMI, and TC; ‡Adjusted for age, HDL-C, FBS, BMI, and TC; §Adjusted for age, TG, FBS, BMI, and TC.

APOA5, apolipoprotein A5; BMI, body mass index; FBS, fasting blood glucose; HDL-C, high density lipoprotein cholesterol; OR, odds ratio; TC, total cholesterol; TG, triglyceride.

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