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Lee, Kim, Kim, Hong, Hyeon, Kim, Kim, and Ahn: A Case of Diabetic Mastopathy
Case Report
Endocrinology and Metabolism

Endocrinology and Metabolism 2012; 27(3): 244-246.

Published online: 19 September 2012

DOI: https://doi.org/10.3803/EnM.2012.27.3.244

A Case of Diabetic Mastopathy

Seok Hong Lee, Bo Min Kim, Jae Woong Kim, Moon-Ki Hong, Seonghyeop Hyeon, Mi Yi Kim, Jaetaek Kim, Jihyun Ahn

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Corresponding author: Jihyun Ahn. Department of Internal Medicine, Chung-Ang University College of Medicine, 84 Heukseok-ro, Dongjak-gu, Seoul 156-861, Korea. Tel: +82-2-6299-3248, Fax: +82-2-6299-1390, drahn@cau.ac.kr

Received 30 November 2011       Accepted 8 February 2012

Copyright © 2012 Korean Endocrine Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetic mastopathy is an unusual fibroinflammatory breast lesion that is characteristically presented in premenopausal women with long-standing diabetes with multiple microvascular complications. This patient was a 49-year-old postmenopausal woman with diabetic nephropathy, neuropathy, and retinopathy. Although palpable mass was detected on the left breast, an ultrasonography could not distinguish it from breast cancer. Excisional biopsy was conducted. Histological findings indicated diabetic mastopathy with keloid-like fibrosis, perivascular lymphocytic infiltration, and lymphocytic lobulitis without evidence of malignancy. After excision, there has been no recurrence until now.

Keywords: Diabetic mastopathy, Diabetes

Figures and Tables

Fig. 1
Ultrasonography shows 1.8 cm sized heterogeneous irregular hypoechoic nodules in (A) right and (B) left breast.
enm-27-244-g001
Fig. 2
(A) Histopathological findings (H&E stain, × 100) show that lymphocytic infiltration around the lobules and ducts. (B) Markedly increased keloid-like collagen and enlarged epithelioid fibroblasts (H&E stain, × 200).
enm-27-244-g002

References

1. Logan WW, Hoffman NY. Diabetic fibrous breast disease. Radiology. 1989. 172:667–670.
2. Byrd BF Jr, Hartmann WH, Graham LS, Hogle HH. Mastopathy in insulin-dependent diabetics. Ann Surg. 1987. 205:529–532.
3. Tomaszewski JE, Brooks JS, Hicks D, Livolsi VA. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol. 1992. 23:780–786.
4. Perez JA, Carrasco C. Diabetic mastopathy. Report of a case. Rev Med Chil. 2003. 131:1305–1308.
5. Membrilla E, Jimeno M, Martinez M, Maria Corominas J, Solsona J, Grande L. Diabetic mastopathy in diabetes mellitus type 2. Endocrinol Nutr. 2009. 56:43–46.
6. Soler NG, Khardori R. Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus. Lancet. 1984. 1:193–195.
7. Schwartz IS, Strauchen JA. Lymphocytic mastopathy. An autoimmune disease of the breast? Am J Clin Pathol. 1990. 93:725–730.
8. Camuto PM, Zetrenne E, Ponn T. Diabetic mastopathy: a report of 5 cases and a review of the literature. Arch Surg. 2000. 135:1190–1193.
9. Lammie GA, Bobrow LG, Staunton MD, Levison DA, Page G, Millis RR. Sclerosing lymphocytic lobulitis of the breast: evidence for an autoimmune pathogenesis. Histopathology. 1991. 19:13–20.
10. Sangthawan P, Fox J, Atkins RC, Kerr PG. Increased incidence of benign breast disease in female renal transplant patients receiving cyclosporin. ANZ J Surg. 2002. 72:222–225.
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