Journal List > Endocrinol Metab > v.26(3) > 1085891

Choi, So, Hwang, Jeong, Ahn, Chung, and Yang: A Case of Adrenocortical Carcinoma Secreting Cortisol, Androgen and Aldosterone


Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane.

Figures and Tables

Fig. 1
Abdominal CT scan showing a large right adrenal mass (maxinum diameter, 10 cm).
Fig. 2
PET-CT shows highly active lesion in right adrenal area.
Fig. 3
Microscopic findings of the surgically removed tumor (H&E stain, × 400).


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