Sedative Effect of Sublingual Midazolam after Oral Chloral Hydrate or Hydroxyzine in Children

Hyunjung Lee; Kwangwoo Baek; Sanghyuk Jung

doi:10.17245/jkdsa.2008.8.1.16

Journal List > J Korean Dent Soc Anesthesiol > v.8(1) > 1084462

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This article has been corrected. See "Erratum: Sedative Effect of Submucosal Midazolam after Oral Chloral Hydrate or Hydroxyzine in Children" in Volume 8 on page 127.

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Lee, Baek, and Jung: Sedative Effect of Sublingual Midazolam after Oral Chloral Hydrate or Hydroxyzine in Children

Original Article

Journal of the Korean Dental Society of Anesthesiology 2008; 8(1): 16-21.

Published online: 30 May 2016

DOI: https://doi.org/10.17245/jkdsa.2008.8.1.16

Sedative Effect of Sublingual Midazolam after Oral Chloral Hydrate or Hydroxyzine in Children

Hyunjung Lee, Kwangwoo Baek, Sanghyuk Jung^*

Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry, Ewha Womans University, Seoul, Korea.

^*Department of Preventive Medicine, College, Ewha Womans University, Seoul, Korea.

Corresponding Author: (pedobaek@ewha.ac.kr)

(open-access, http://creativecommons.org/licenses/by-nc/3.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently combining regimen of minimal doses of chloral hydrate, hydroxyzine and midazolam is good in sedation of children. Midazoalm, water soluble benzdiazepine, has rapid onset and relatively short duration of action. And midazolam has prospective amnesic effect. With these advantages midazolam is popular in conscious sedation for children.

This study was to reveal the dose-dependency of behavior and physiologic effects of sublingual midazolam. Sedation records were surveyed retrospectively, of which the patients admitted from April, 2005 to July, 2007. we assigned three groups according the dose of midazolam, 0.1 mg/kg, 0.2 mg/kg and 0.3 mg/kg, respectively and the behavioral evaluation was analyzed with Houpt scale statistically.

Combined sublingual midazolam increased the success rate in sedation and the vital signs were stable during sedation.

Keywords: Conscious sedation, Submucosal midazolam, Chloral hydrate, Hydroxyzine

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