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Yu, Kim, Jung, and Baek: Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen (SpO2), End-tidal Carbon Dioxide (EtCO2) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation
Original Article

Journal of the Korean Dental Society of Anesthesiology 2006; 6(2): 89-97.

Published online: 1 June 2016

DOI: https://doi.org/10.17245/jkdsa.2006.6.2.89

Effect of Submucosal Midazolam on Percutaneous Saturation Percentage of Oxygen (SpO2), End-tidal Carbon Dioxide (EtCO2) and Physiologic Response When Combined with Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation

Jihye Yu, Yunhee Kim, Sanghyuk Jung*, Kwangwoo Baek

Department of Pediatric Dentistry, Ewha Womans University Graduate School of Clinical Dentistry, Seoul, Korea.

*Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

Corresponding Author: (pedobaek@ewha.ac.kr)

Copyright © 2006 Journal of the Korean Dental Society of Anesthesiology

(open-access, http://creativecommons.org/licenses/by-nc/3.0/):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

The aim of this study was to examine the difference of SpO2, PR, EtCO2, RR with submucosal injection of midazolam to oral chloral hydrate and hydroxyzine for pediatric patients

Methods

Thirty two sedation cases were performed in this study. Patients were randomly classified into one group taking oral CH (60 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.1 mg/kg) and the other group recieving oral CH (50 mg/kg), hydroxyzine (1 mg/kg) and submucosal injection of midazolam (0.2 mg/kg). For evaluating the depth of sedation, data including saturation percentage of oxygen (SpO2), pulse rate (PR), end-tidal carbon dioxide (EtCO2), respiratory rate (RR) and the behavior scale were checked every 2 minutes and were collected for only 40 minutes from the beginning of treatment and were analyzed using Two independent sample T-test.

Results

Analysis showed no significant difference in the mean SpO2, PR, EtCO2, RR during sedation between two groups (P>0.05). The values of SpO2, PR, EtCO2 and RR for both groups remained within the normal values.

Conclusions

The results of this present study indicate that combination of oral CH, hydroxyzine, nitrous oxide gas inhalation and submucosal injection of midazolam improved the sedation quality without compromising safety.

Keywords: Conscious sedation, Submucosal midazolam, Chloral hydrate, Nitrous oxide

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