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Abstract
Purpose:
To analyze the distribution of human papillomavirus (HPV) types and the characteristics of genital condyloma in Korean men.
Materials and Methods:
Between January 2015 and December 2015, we reviewed the medical charts of 435 male patients diagnosed with genital condyloma. A total of 441 samples were identified. The detection rate of each HPV type and its associated characteristics (age, number of HPV types, low-risk and/or high-risk types, number of lesions) were analyzed. Our sample population was divided into two groups: The non-urethral condyloma group and the urethral condyloma group. In addition, subgroup analysis was also performed.
Results:
Among the total 441 specimens, 409 (92.7%) were non-urethral condyloma and 32 (7.3%) were urethral condyloma. Single-type infection was observed in 56.7% and multiple-type infection was seen in 43.3%. HPV type 6 and type 11 were the most common types in total genital condyloma and subgroups. HPV type 11, which was detected in 43.8% of those in the urethral condyloma group and in 22.0% of those in the non-urethral condyloma group (p=0.009), showed a statistically significant difference with respect to the type-specific detection rate.
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Table 1.
The characteristics of specimens in the non-urethral and urethral condyloma groups
| Characteristic | Total N genital condyloma (n=441) | Non-urethral condyloma (n=409) | Urethral condyloma (n=32) | p-valuea) |
|---|---|---|---|---|
| Mean age (y) | 32.1±6.9 | 31.0±9.0 | 32.2±6.7 | 0.283 |
| Age (y) | 0.120 | |||
| ≤30.0 | 174 (39.5) | 156 (38.1) | 18 (56.3) | |
| 30.1-40.0 | 211 (47.8) | 200 (48.9) | 11 (34.4) | |
| ≥40.1 | 56 (12.7) | 53 (13.0) | 3 (9.4) | |
| Number of HPV types | 0.356 | |||
| Single type | 250 (56.7) | 229 (56.0) | 21 (65.6) | |
| Multiple type | 191 (43.3) | 180 (44.0) | 11 (34.4) | |
| Low- and/or high-risk type | 0.914 | |||
| Low | 284 (64.4) | 263 (64.3) | 21 (65.6) | |
| High | 12 (2.7) | 12 (2.9) | 0 (0.0) | |
| High & low | 145 (32.9) | 134 (32.8) | 11 (34.4) | |
| Number of lesions | 0.059 | |||
| Single | 105 (23.8) | 93 (22.7) | 12 (37.5) | |
| Multiple | 336 (76.2) | 316 (77.3) | 20 (62.5) | |
Table 2.
Distribution rate of HPV types in genital condyloma
| HPV type | Total genital condyloma (n=441) | Non-urethral condyloma (n=409) | Urethral condyloma (n=32) | p-valuea) |
|---|---|---|---|---|
| Low-risk type | ||||
| 6 | 308 (69.8) | 290 (70.9) | 18 (56.2) | 0.108 |
| 11 | 104 (23.6) | 90 (22.0) | 14 (43.8) | 0.009 |
| 40 | 30 (6.8) | 30 (7.3) | 0 (0.0) | 0.152 |
| 42 | 21 (4.8) | 21 (5.1) | 0 (0.0) | 0.387 |
| 43 | 28 (6.3) | 27 (6.6) | 1 (3.1) | 0.710 |
| 44 | 18 (4.1) | 18 (4.4) | 0 (0.0) | 0.632 |
| 54 | 12 (2.7) | 12 (2.9) | 0 (0.0) | 1.000 |
| 61 | 7 (1.6) | 6 (1.5) | 1 (3.1) | 0.412 |
| High-risk type | ||||
| 16 | 27 (6.1) | 23 (5.6) | 4 (12.5) | 0.122 |
| 18 | 14 (3.2) | 13 (3.2) | 1 (3.1) | 1.000 |
| 26 | 2 (0.5) | 2 (0.5) | 0 (0.0) | 1.000 |
| 31 | 8 (1.8) | 7 (1.7) | 1 (3.1) | 0.455 |
| 33 | 8 (1.8) | 7 (1.7) | 1 (3.1) | 0.455 |
| 35 | 15 (3.4) | 15 (3.7) | 0 (0.0) | 0.615 |
| 39 | 11 (2.5) | 9 (2.2) | 2 (6.3) | 0.186 |
| 45 | 10 (2.3) | 8 (2.0) | 2 (6.3) | 0.159 |
| 51 | 10 (2.3) | 9 (2.2) | 1 (3.1) | 0.533 |
| 52 | 12 (2.7) | 12 (2.9) | 0 (0.0) | 1.000 |
| 53 | 30 (6.8) | 28 (6.8) | 2 (6.3) | 1.000 |
| 56 | 12 (2.7) | 12 (2.9) | 0 (0.0) | 1.000 |
| 58 | 14 (3.2) | 12 (2.9) | 2 (6.3) | 0.270 |
| 59 | 15 (3.4) | 15 (3.7) | 0 (0.0) | 0.615 |
| 66 | 15 (3.4) | 15 (3.7) | 0 (0.0) | 0.615 |
| 68 | 8 (1.8) | 7 (1.7) | 1 (3.1) | 0.455 |
| 69 | 0 (0.0) | 0 (0.0) | 0 (0.0) | - |
| 70 | 7 (1.6) | 7 (1.7) | 0 (0.0) | 1.000 |
| 73 | 6 (1.4) | 6 (1.5) | 0 (0.0) | 1.000 |
| 82 | 8 (1.8) | 8 (2.0) | 0 (0.0) | 1.000 |
Table 3.
Comparison of low and/or high risk human papillomavirus type between single- and multiple-type infections
Table 4.
Detection rate of high risk human papillomavirus type by age
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