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Park, Kim, Cho, Jeong, Choi, Kwon, Lim, Hahm, and Park: Primary Aldosteronism Presenting as Hypokalemia and Rhabdomyolysis
Case Report

J Korean Ophthalmol Soc 2016;18(1):21-24.

Published online: 18 January 2016

DOI: https://doi.org/10.14253/kjcn.2016.18.1.21

Primary Aldosteronism Presenting as Hypokalemia and Rhabdomyolysis

Kee Hong Park1, 5, Soo-Kyung Kim1, 5, Eun Bin Cho2, 5, Heejeong Jeong2, 5, Nack-Cheon Choi1, 3, 5, Oh-Young Kwon1, 3, Byeong Hoon Lim1, 3, 5, Jong Ryeal Hahm1, 4, 5, Ki-Jong Park2, 3, 5

1Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea

2Department of Neurology, Gyeongsang National University Changwon Hospital, Changwon, Korea

3Department of Neuroology and School of Medicine, Gyeongsang National University, Jinju, Korea

4Internal Medicine, School of Medicine, Gyeongsang National University, Jinju, Korea

5Institute of Health Science, Gyeongsang National University, Jinju, Korea

Address for correspondence; Ki-Jong Park Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, 11 Samjeongja-ro, Seongsan-gu, Changwon 51472, Korea Tel: +82-55-214-3810 Fax: +82-55-214-3255 E-mail: pkjong@gnu.ac.kr

Received 24 February 2016       Revised 13 May 2016       Accepted 17 May 2016

Copyright © 2016 Korean Ophthalmological Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary aldosteronism is one of the most common cause of secondary hypertension and can be accompanied with hypokalemia. Rhabdomyolysis with hypokalemia in primary aldosteronism has been rarely reported. We describe a patient of primary aldosteronism who presented with limb-girdle type weakness. (Korean J Clin Neurophysiol 2016;18:21-24)

Keywords: Rhabdomyolysis, Primary aldosteronism, Hypokalemia

REFERENCES

1.Funder JW., Carey RM., Fardella C., Gomez-Sanchez CE., Mantero F., Stowasser M, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: An endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2008. 93:3266–3281.
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2.Omura M., Sasano H., Saito J., Yamaguchi K., Kakuta Y., Nishikawa T. Clinical characteristics of aldosterone-producing microadenoma, macroadenoma, and idiopathic hyperaldosteronism in 93 patients with primary aldosteronism. Hypertens Res. 2006. 29:883–889.
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3.Lee JH., Kim E., Chon S. Hypokalemia-induced rhabdomyolysis by primary aldosteronism coexistent with sporadic inclusion body myositis. Ann Rehabil Med. 2015. 39:826–832.
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4.Park W., Kim DH., Han KC., Bae YH., Kim SH., Ju JH, et al. A case of primary aldosteronism with rhabdomyolysis. Korean J Nephrol. 2005. 24:845–850.
5.Kim B., No HJ., Lim YH., Kim HJ., Kim HY., Park BH, et al. A case of primary aldosteronism accompanied by rhabdomyolysis. Korean J Med. 2006. 70:261–266.
6.Kim HI., Baek SA., Hwang HS., Lee WH., Kang GW., Lee IH. A case of primary aldosteronism accompanied by hypokalemic rhabdomyolysis. Yeungnam Univ J Med. 2012. 29:113–117.
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7.Chao CT., Wu VC., Kuo CC., Lin YH., Chang CC., Chueh SJ, et al. Diagnosis and management of primary aldosteronism: an updated review. Ann Med. 2013. 45:375–383.
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Figure 1.
Abdomen computer tomography. Computed tomography shows a 2.3 cm sized enhancing nodule in left adrenal gland (arrow).
kjcn-18-21f1.tif
Table 1.
Summarization of previous Korean cases
Age Sex Duration of weakness Duration of hypertension Anti-hypertensive medication Serum potassium (mmol/L) Serum CK (IU/L) Size of adrenal nodule (cm) Pathology
13 54 Male 14 days 5 years Thiazide, CCB, ARB, BB 2 2,982 1.5 Adenoma
24 58 Female 3-4 days 17 years Thiazide 1.4 12,792 1.6 Adenoma
35 45 Female 5 days 1 year Unknown 2.7 9,265 1.5 Adenoma
46 48 Male 7 days 3 years CCB, ARB 1.8 12,786 2 Adenoma
Present case 36 Female 3 days 5 months Thiazide, CCB, ARB 1.8 1,744 2.3 Adenoma

CK; creatine kinase, CCB; calcium channel blocker, ARB; angiotensin receptor blocker, BB; beta blocker.

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