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Kim and Kim: A Case of Squamous Cell Lung Cancer Representing as Guillain-Barre Syndrome Associated with Monospecific Anti-GD1b IgG
Original Article

Korean J Community Nutr 2015;17(1):31-34.

Published online: 18 December 2015

DOI: https://doi.org/10.14253/KJCN.2015.17.1.31

A Case of Squamous Cell Lung Cancer Representing as Guillain-Barre Syndrome Associated with Monospecific Anti-GD1b IgG

Yeshin Kim, Seongheon Kim

Department of Neurology, Kangwon National University School of Medicine, Chuncheon, Korea

Address for correspondence; Seongheon Kim Department of Neurology, Kangwon National University School of Medicine, 1 Gangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, Korea Tel: +82-33-258-2413 Fax: +82-33-258-9489 E-mail: dr.kim94@gmail.com

Received 26 November 2014       Revised 31 March 2015       Accepted 3 June 2015

Copyright © 2015 Journal of the Korean Society of Community Nutrition

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case with squamous cell lung cancer with concomitant Guillain-Barre syndrome (GBS) as a paraneoplastic syndrome. A 67-year-old patient who was previously diagnosed as metastatic squamous cell lung cancer developed mild symmetrical weakness, paresthesia and sensory ataxia. Nerve conduction study showed sensorimotor polyneuropathy. Analysis of cerebrospinal fluid showed high tilter for monospecific anti-GD1b IgG antibody without onco-neuronal antibodies. After treatment with intravenous immunoglobulin, the patient’s symptoms improved. (Korean J Clin Neurophysiol 2015;17:31-34)

Keywords: Guillain-Barre syndrome, Paraneoplastic syndrome, Anti-GD1b antibody

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Table
Summary of pathomechanism-based clinical trials for ALS
Motor nerves (R/L) Initial After 11 days After 18 days Normal
Lat (ms) Amp (mV) CV (m/s) Lat (ms) Amp (mV) CV (m/s) Lat (ms) Amp (mV) CV (m/s) Lat (ms) Amp (mV) CV (m/s)
Median nerve Wrist 3.5/3.8 7.7/7.6 3.3/4.0 7.4/6.6 3.6 5
Elbow 7.1/7.4 50/47 7.0/5.4 48/48 5 49.96
F-wave latency 35.4/33.9 35.0/32.5 27.57
Ulnar nerve Wrist 3.2/3.2 3.6/7.4 3.0/3.6 4.4/8.2 2.51 5
Elbow 1.8/6.1 38/45 2.6/7.2 36/45 5 50.61
F-wave latency 39.5/40.3 41.0/37.8 27.63
Peroneal nerve Ankle 4.7/5.0 4.3/3.6 4.5/4.5 3.0/3.1 6.0/4.6 2.4/6.0 4.78 4
Fibular head 3.0/3.2 39/38 2.8/2.8 37/37 2.1/4.1 35/37 4 41.85
F-wave latency 63.6/NP 64.8/58.5 71.4/59.3 46.13
Tibial nerve Ankle 4.1/4.4 15.9/14.5 4.9/4.6 15.1/13.3 5.0/5.2 13.2/11.2 5.11 5
Popliteal fossa 9.7/10.6 36/37 9.6/9.8 37/37 8.7/9.1 37/44 5 40.63
F-wave latency 62.9/56.9 61.0/57.9 60.2/59.1 49.55
H-wave latency NP/NP NP/NP NP/NP 29.47
Sensory nerves (R/L) Amp (//V) CV (m/s) Amp (//V) CV (m/s) Amp (//V) CV (m/s) Amp QN) CV (m/s)
Median nerve Finger-wrist NP/NP NP/NP NP/NP 10 41.26
Wrist-elbow NP/NP 9/NP 45/NP 10 49.39
Palm-wrist NP/NP 10/NP 31/NP 10 34.05
Ulnar nerve Finger-wrist NP/NP NP/NP 10 39.26
Wrist-elbow NP/NP NP/NP 10 47.46
Sural nerve 5.0/6.0 31/32 NP/NP NP/NP 6 34.68

R; right, L; left, ?at; latency, Amp; amplitude, CV; conduction velocity, NP; no potential.

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