Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function

Sangkil Lee; Il-gi Yoon; Jung-Jun Park; Jae Il Kim; Geun-ho Lee; Jee Hyun Kim

doi:10.14253/kjcn.2013.15.1.34

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Lee, Yoon, Park, Kim, Lee, and Kim: Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function

Brief Communication

Korean J Community Nutr 2013;15(1):34-36.

Published online: 19 January 2013

DOI: https://doi.org/10.14253/kjcn.2013.15.1.34

Acyclovir-Induced Encephalopathy in a Patient with Normal Renal Function

Sangkil Lee, Il-gi Yoon, Jung-Jun Park, Jae Il Kim, Geun-ho Lee, Jee Hyun Kim

Department of Neurology, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea

Address for correspondence; Jee Hyun Kim Department of Neurology, Dankook University Hospital, Dankook University College of Medicine, 201 Manghyang-ro, Dongnam-gu, Cheonan 330-715, Korea Tel: +82-41-550-3292 Fax: +82-41-556-6245 E-mail: fever26@gmail.com

Received 21 December 201222 March 2013 Accepted 29 May 2013

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Acyclovir, Normal renal function, Encephalopathy

REFERENCES

1.Peces R., de la Torre M., Alcázar R. Acyclovir-associated encephalopathy in haemodialysis. Nephrol Dial Transplant. 1996. 11:752.

2.Revankar SG., Applegate AL., Markovitz DM. Delirium associated with acyclovir treatment in a patient with renal failure. Clin Infect Dis. 1995. 21:435–436.

3.Rashiq S., Briewa L., Mooney M., Giancarlo T., Khatib R., Wilson FM. Distinguishing acyclovir neurotoxicity from encephalomyelitis. J Intern Med. 1993. 234:507–511.

4.Laskin OL., Longstreth JA., Whelton A. Acyclovir kinetics in end-stage renal disease. Clin Pharmacol Ther. 1982. 31:594–601.

5.Hellde´n A., Odar-Cederlof I., Diener P., Barkholt L., Medin C., Svensson JO, et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol Dial Transplant. 2003. 18:1135–1141.

6.Hellde´n A., Lycke J., Vander T., Svensson JO., Odar-Cederlof I., Stahle L. The acyclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during acyclovir and valaciclovir treatment. J Antimicrob Chemother. 2006. 57:945–949.

7.Smith JP., Weller S., Johnson B., Nicotera J., Luther JM., Haas DW. Pharmacokinetics of Acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function. Antimicrob Agents Chemother. 2010. 54:1146–1151.

Figure 1.

EEG findigns. (A) Initial EEG shows generalized theta slowing without epileptiform discharge. (B) Follow-up portable EEG with 8 channels reveals generalized theta to delta waves with low amplitude after the treatment of intravenous acyclovir.

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