The Usefulness of CT Brain Perfusion Image on Evaluation of Traumatic Brain Injury

Ji Woong Oh; Hyen Ho Jung; Jhin Soo Pyen; Chul Hu; Kum Whang; Myeong Sub Lee

doi:10.13004/jknts.2010.6.1.6

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Oh, Jung, Pyen, Hu, Whang, and Lee: The Usefulness of CT Brain Perfusion Image on Evaluation of Traumatic Brain Injury

Clinical Article

Journal of Korean Neurotraumatology Society 2010; 6(1): 6-12.

Published online: 30 June 2010

DOI: https://doi.org/10.13004/jknts.2010.6.1.6

The Usefulness of CT Brain Perfusion Image on Evaluation of Traumatic Brain Injury

Ji Woong Oh, MD¹, Hyen Ho Jung, MD¹, Jhin Soo Pyen, MD¹, Chul Hu, MD¹, Kum Whang, MD¹, Myeong Sub Lee, MD²

¹Department of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.

²Department of Radiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.

Address for correspondence: Kum Whang, MD. Department of Neurosurgery, Wonju College of Medicine, Yonsei University, 162 Ilsan-dong, Wonju 220-701, Korea. Tel: +82-33-741-0592, Fax: +82-33-746-2287, whangkum@yonsei.ac.kr

Received 30 April 2010 Revised 6 May 2010 Accepted 26 May 2010

Abstract

Objective

The purpose of this study is to evaluate the finding of computed tomography brain perfusion (CBP) in early traumatic brain injury patient.

Methods

33 patients with head trauma were evaluated and the patients were classified into 4 categories: traumatic subarachnoid hemorrhage (T-SAH), actue epidural hematoma (EDH), acutue subdural hematoma (SDH), traumatic intracerebral hemorrhage (T-ICH). We evaluated the cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT) of the lesion vs contralateral lesion, lesion's hemisphere and brain stem vs contralateral side and compared them.

Results

T-SAH was found in 7 cases. And the all T-SAH patients have no perfusion defect and they have no ischemic change on follow up brain CT. EDH was found in 11 cases. 3 of the 11 EDH patients have perfusion defect that was not revealed by non-contrast CT. According to the EDH size, brain stem perfusion value was different. And at the same size of EDH, the value was low if patients have low initial GCS. SDH was found in 9 cases. The 2 cases have different operation. Decompressive craniectomy was made for one patient who have low perfusion value of brain stem. And osteoplastic craniotomy was made for the other patient who have relative high perfusion value. The low perfusion value of brain stem was correleated with brain swelling. T-ICH was found in 12 cases. Contusion sites have decreased perfusion value and the DTICH (delayed traumatic intracerebral hemorrhage) was developed perfusion defect area on initial CT brain perfusion.

Conclusion

The CBP give us meaningful information of traumatic brain injury that associated with patient's unexplained symptom, and may be useful for deciding operative plan, and predicting the prognosis of the patient.

Keywords: CT brain perfusion, Traumatic brain injury

Figures and Tables

FIGURE 1

The example of ROI setting. The pre contrast CT brain showd the ICH on Lt temporal. The work station showed us source image. We draw the ROI on perfusion defect area of ICH. The CBF, CBV was calculated automatically. ROI: region of interest. ICH: intracerebral hemorrhage, CBF: cerebral blood flow, CBV: cerebral blood volume.

FIGURE 2

Perfusion defect area that not revealed non-contrast CT. The patient contusion site (large arrow) which was not revealed by noncontrast CT.

FIGURE 3

The comparison of perfusion value of brain stem in EDH patients. A: The perfusion value of Non-operative group was higher than operative group. B: 38 yrs old female. C: 5 yrs male. B have higher perfusion value of brain stem than C. And Initial GCS of B was also higher than C. CBV: cerebral blood volume, CBF: cerebral blood flow, MTT: mean transit time, EDH: epidural hematoma, GCS: Glasgow Coma Scale.

FIGURE 4

The comparison of operation case in acute subdural hematoma. A, C: 95 yrs old male. No brain swelling was noted in operating field. So osteoplastic craniotomy and hematoma evacuation was done. The perfusion value of brain stem was normal range. B, D: 72 yrs old male. Severe brain swelling was noted. And so decompressive craniectomy and hematoma evacuation operation was done. Low perfusion value of brain stem was checked. CBF: cerebral blood flow.

FIGURE 5

The comparison of perfusion value in case that have Right SDH and Left EDH. Both injuries required emergency operation. The sum of perfusion value in right hemisphere was relatively lower than that of Left hemisphere, suggesting that more stress was affecting the right side. SDH: subdural hematoma, EDH: epidural hematoma, CBV: cerebral blood volume, CBF: cerebral blood flow.

FIGURE 6

DT-ICH on perfusion defect area. On F/U CT brain image, DT-ICH was newly developed on Right Frontal area and that is correlated with initial perfusion defect area. DT-ICH: delayed traumatic intracerebral hemorrhage. F/U: follow up, GCS: Glasgow Coma Scale, CBF: cerebral blood flow, CBV: cerebral blood volume, MTT: mean transit time.

FIGURE 7

Perfusion value of both hemisphere in traumatic brain injury patients. The un injured side's hemisphere had better blood flow and volume than injured side's (Paired t-test, p<0.0142).

FIGURE 8

Hemorrhage and CBF of all axial cut image in a case. Our calculation showed better CBF in the control group as a whole. However, in one or two axial images, flows on lesion resulted better than the control group. CBF: cerebral blood flow.

FIGURE 9

Mental status and brain stem perfusion. The CBF and CBV of non-severe group were higher than severe group. But no statistical importance was found. CBV: cerebral blood volume, CBF: cerebral blood flow, MTT: mean transit time, GCS: Glasgow Coma Scale.

TABLE 1

ICH contusion site's perfusion value. CBV, CBF were generally decreased in contusion sites

^*mL/100g/min, ^†mL/100g, ^‡second (nomal range of CBV, CBF: 3.8±0.5 mL/100mL, 50-100 mL/100g/minute). CBF: cerebral blood flow, CBV: cerebral blood volume, MTT: mean transit time

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