Intracranial hypotension seems to be caused by cerebrospinal fluid (CSF) leakage from a spinal meningeal diverticulum or dura tear. It is characterized by orthostatic headache and diffuse meningeal enhancement on gadolinium-enhanced brain magnetic resonance imaging. Site of CSF leakage could be disclosed with radioisotope cisternography, and computed tomography myelography is useful when cisternography failed to unravel anatomical information. Epidural blood patch is very effective to stop the leakage. We report a case of orthostatic headache caused by intracranial hypotension in a 32-year-old woman. Computed tomography myelography confirmed a CSF leakage in the area of left L2 nerve root. The patient was successfully treated by epidural blood patch.