Repetitive motion injuries (RMI), also called repetitive stress injuries (RSI), are temporary or permanent injuries to nerves, muscles, ligaments, and tendons caused by performing the same motion over and over again. Tens of thousands of injuries each year are caused by repetitive motions. There are different ways injuries can happen, but they all result from stress or strain imposed on some part of the body from a task's repetitive nature. This includes typing, computer mouse use and recurring motions such as twisting, turning and grasping. RMI can be quite painful and become progressively worse without treatment, possibly resulting in complete loss of function in the affected area. Tingling, numbness, or pain in the affected area, and loss of flexibility or strength are common symptoms. Hands, fingers, wrists, elbows, shoulders and backs are the most common areas affected. Tendons connect the muscles to the bones. If movement is repeated too often without rest, the tendons surrounding the muscles can become inflamed and blood flow becomes restricted. When tendons become inflamed, they can press against nerves often resulting in numbness and tingling. The main purpose of this review is providing how to prevent and manage RMI of peripheral nerve especially in computer-related workers.