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Seo, Lee, and Kang: Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients
Original Article

The Ewha Medical Journal 2005; 28(2): 87-92.

Published online: 30 September 2005

DOI: https://doi.org/10.12771/emj.2005.28.2.87

Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients

So Yeon Seo, JiSoo Lee, Eun-Suk Kang

Department of Laboratory Medicine, College of Medicine, Ewha Womans University, Korea.

Copyright © 2005. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives

To evaluate the clinical significances of antibodies to cyclic citrullinated peptides (anti-CCP) and IgM Rheumatoid Factor(RF) in patients with established rheumatoid arthritis.

Methods

The subjects included 86 established RA patients according to the revised ACR criteria and 46 non-RA patients presenting joint manifestations and 61 healthy individuals as control. Anti-CCP and IgM RF were measured by ELISA and nephelometric method, respectively.

Results

The sensitivity and specificity of anti-CCP were 64% and 98% and of IgM RF were 69% and 76%, respectively. Eleven (4 I %) out of 27 sero-negative RA patients had elevated anti-CCP. Combination of anti-CCP with IgM RF increased diagnostic sensitivity and specificity of RA to 81% and 99%, respectively.

Conclusion

Simultaneous measurement of IgM RF and anti-CCP for the initial evaluation of arthritis would increase the diagnostic efficacy of RA.

Keywords: Rheumatoid arthritis, Anti-CCP antibodies, IgM rheumatoid factor

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