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Kim: The Expression of bFGF m-RNA in the Gastric Cancer Tissues
Original Article

The Ewha Medical Journal 1999; 22(1): 17-21.

Published online: 30 March 1999

DOI: https://doi.org/10.12771/emj.1999.22.1.17

The Expression of bFGF m-RNA in the Gastric Cancer Tissues

Young-Woo Kim

Department of Surgery, College of Medicine, Ewha Womans University, Korea.

Copyright © 1999. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Backgrounds

The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.

Methods

Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.

Results

In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.

Conclusions

In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.

Keywords: Gastric cancer, Basic fibroblast growth factor, In situ hybridization, mRNA

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