Levofloxacin, an oral fluroquinolone antibacterial agent, is the optical S-(-) isomer of ofloxacin. In vitro it is generally twice as potent as ofloxacin and active against most aerobic gram positive and gram negative organisms, but only moderate activities against anaerobics.

Our purpose was to investigate the therapeutic efficacy and tolerability of levofloxacin in patients with several kinds of cutaneous infections.

Levofloxacin(CRAVIT®; Korea Daiich Parm. Co.) 300-600mg/day for 5-14days was administrated to eighteen patients with cutaneous and subcutaneous infections. The Bacterial culture and laboratory tests were performed prior to and after treatments. Clinical effects and adverse events were evaluated on laboratory indics.

1) Nine of thrteen cases(70%) were useful, four cases(30%) were slightly useful.

2) Clinically twelve of eighteen cases were cured and eight cases were partial response to the drug.

3) There were no laboratory abnormalities after levofloxacin treatment

4) Side effects were not significant except dizziness and sleep disturbance.

Levofloxacin was evaluated as a highly effective antibacterial agent against dermatologic infections.