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Choi and Park: Striatal Network Model in Parkinson Disease: Preliminary Study
Original Article

The Ewha Medical Journal 1996; 19(2): 221-226.

Published online: 24 July 2015

DOI: https://doi.org/10.12771/emj.1996.19.2.221

Striatal Network Model in Parkinson Disease: Preliminary Study

Kyoung Gyu Choi, Kee Duk Park

Department of Neurosurgery, Ewha Womans University Medical School, Korea.

Copyright © 1996. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease.

Methods

We use an approach to studying the function of neural systems that is based on the use of a class of computer models known as parallel distributed processors(PDPs).And the focus of this study is the nigrostriatal dopaminergic effects on the corticostriatal fibers and the striatal medium spiny neurons.

Results

A model that explains hypokinesia in Parkinson disease is presented for the opation of the striatum.

Conclusions

In order to study the brain funcion and mechanism of physiopathology, te-stable theories that consider brain as a whole system are needed. We think neural network model with PDPs would be an important field in neuroscience in near future.

Keywords: Neural network, Parallel distributed processors, Parkinson disease

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