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Yoon: Experimental Study of The Influence of the Calcium Channel Blockers on Flap Survival
Original Article

The Ewha Medical Journal 1994; 17(2): 109-115.

Published online: 24 July 2015

DOI: https://doi.org/10.12771/emj.1994.17.2.109

Experimental Study of The Influence of the Calcium Channel Blockers on Flap Survival

Chin Ho Yoon

Department of Plastic Surgery, College of Medicine, Ewha Womans University, Korea.

Copyright © 1994. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flap surgery and its survival is a major interest of the plastic surgeon. There have been numerous investigations concerned with finding a safe and effective method for increasing the area of skin flap survival. As the delay phenomenon theory, that is vascular smooth muscle relaxation auguments the blood flow to the capillary bed of the skin flap, experimental study using the Sprague-Dawley rats was perforned with the calcium antagonists which cause the dilatation of vascular smooth muscle by blocking the calcium influx into the cells.
The experimental results were as followings :
Survival area increased up to 72.7% with verapamil treatment and 81.22% with nimodipine treatment compared to 58.62% in the control. There was no significant difference between verapamil and nimodipine treatment groups.

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