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Kyung: Improvement of Insulin Secretoruy Capacity According to Insulin Therapy in Non-Insulin Depentent Diabetes Mellitus
Original Article

The Ewha Medical Journal 1990; 13(2): 93-100.

Published online: 24 July 2015

DOI: https://doi.org/10.12771/emj.1990.13.2.93

Improvement of Insulin Secretoruy Capacity According to Insulin Therapy in Non-Insulin Depentent Diabetes Mellitus

Nan Ho Kyung

Department of Internal Medicine, College of Medicine, Ewha Womans University, Korea.

Copyright © 1990. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To evaluate whether the urinary and serum c-peptide is the indicator of insulin therapy in NIDDM, and whether the insulin secretery capacity improves after control of blood glucose, We measured 24 hour urinary c-peptide excretion, fasting and postprandial 2hour's serum c-peptide concentrations before and after insulin therapy in 20 patients with NIDDM.
The results were as follows ;
1) The postprandial 2 hour's serum c-peptide level was significantly lower in patients with NIDDM than normal controls, bu t fasting serum c-peptide level and 24hour urinary c-peptide excretion showed no significant difference between normal control group and patients with NIDDM
2) There was no significant difference in duration of disease, body mass index, fasting serum c-peptide level and 24 hour urinary c-peptide excretion between insulin-requiring group and non-insulin-requiring group among patients with NIDDM. But post prandial 2 hour's serum c-peptide level was significantly lower in insulin requiring group than non-insulin-requiring group before treatment.
3) After therapy with insulin, post prandial 2 hour's serum c-peptide level increased significantly in insulin requiring group, but fasting serum c-peptide and 24 hour urinary c-peptide excretion were not changed significantly after therapy with insulin comparing with the level before therapy.
Author concluded that postprandial 2 hour's serum c-peptide level was a market of insulin therapy in patients with NIDDM and insulin secretory capacity improved after controlling of blood glucose.

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