In 1967, Mehregan et al described a new and distinct clinicopathologic entily that called reactive pergorating collagenosis. This rare disease is classfied with a group of disorders that involve the transepithelial elimination of hestochemically altered dermal tissue. In reactive perforating collagenosis, minor trauma such as an insect bite, scratch, or pliodrbaceous infection alters the collagen fibers in the dermis. We report here a case of reactive perforating collagenosis in a 54-year-old female patient without any associated disseases of specific family history.