Twenty patients with dandurff were treated for 3 weeks by 2.5% selenium sulfide shampoo, 0.15% zine pyrithione shampoo, 2% ketoconazole shampoo, 0.1% hyprocortisone butyrate lotion. All of 4 groups, there corneocyte & nucleocyte counts were decresed remarkably after treatment. And then, we thought that it may be the more effective treatment with low side effect, if adequate combination of these medicated shampoos and topical steroid were used in dandruff and sebrorrheic dermatitis patients.