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Chun, Min, and Jang: Study on the Efficacy of the Experimentally Prepared Nitroxynil-Levamisole Compound Injection Against Liver a Fluck and Gastrointestinal Roundworms in Ruminants
Original Article

The Ewha Medical Journal 1990; 13(3): 139-148.

Published online: 24 July 2015

DOI: https://doi.org/10.12771/emj.1990.13.3.139

Study on the Efficacy of the Experimentally Prepared Nitroxynil-Levamisole Compound Injection Against Liver a Fluck and Gastrointestinal Roundworms in Ruminants

Kae Shik Chun, Hong Ki Min, Du-Hwan Jang

Health Hygiene, Korea Sports Science College, Korea.

Department of Parasitology, College of Medicine, Ewha Womans University, Korea.

College of Veterinary Medicine, Seoul National University, Korea.

Copyright © 1990. Ewha Womans University School of Medicine

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was carried out to evaluate the efficacy of the experimentally prepared injection of nitroxynil-levamisole against liver fluke and gastrointestinal roundworms in goats and cattle. For the purpose, the dose confirmation trial, the dose reduction trial and clinical field trial were conducted according to "the guidelines for evaluating the efficacy of anthelmintics in ruminants" approved by the General Meeting of the 9th International Conference of the World Association for the Advancement of Veterin ary Parasitology" in 1981.
The results obtained are summarized as follows ;
1) A single dose of 10mg/kg of nitroxynil injection alone against the liver fluke and that of 5.0mg/kg of levamisole injection alone against gastrointestinal roundworms in goats were highly effective in the cure rate and the egg reduction rate, respectively.
2) A single dose of the experimentally prepared compound injection at the dose levels of nitroxynil 10.0mg-12.0mg/kg and levamisole 5.0mg-6.0mg/kg was highly effective in the egg reduction rates of both liver fluke(98.4%-100%) and gastrointestinal roundworms(97.3%-98.4%) without any side reaction in goats.
3) A single does of the experimentally prepared compound injection at the reduced dose level of nitroxynil 7.5mg/kg and levamisole 5.0mg/kg was highly effective in the egg reduction rates of both liver fluke and gastrointestinal roundworms in goats.
4) In the clinical field trial, a single dose of the experimentally prepared compound injection at the reduced dose level of nitroxynil 7.5mg/kg and levamisole 5.0mg/kg showed also very high efficacy in the cure rates and the egg reduction rates of both liver fluke and gastrointestinal roundworms in Korean cattle, dairy cow and beef cattle. However, it was not effective against Ostertagia sp. among gastrointestinal roundworms. No side reactions were noted.

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