Thyroid Hemiagenesis Associated with Papillary Thyroid Carcinoma

Inhye Park; Jun Ho Choi; Jung-Han Kim; Jee Soo Kim

doi:10.11106/ijt.2016.9.1.43

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Park, Choi, Kim, and Kim: Thyroid Hemiagenesis Associated with Papillary Thyroid Carcinoma

Case Report

Int J Thyroidol 2016;9(1):43-46.

Published online: 20 May 2016

DOI: https://doi.org/10.11106/ijt.2016.9.1.43

Thyroid Hemiagenesis Associated with Papillary Thyroid Carcinoma

Inhye Park, Jun Ho Choi, Jung-Han Kim, Jee Soo Kim

Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Correspondence: Jee Soo Kim, MD, PhD, Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea Tel: 82-2-3410-0253, Fax: 82-2-3410-6982, E-mail: jskim0126@skku.edu

Received 21 October 2015 Revised 25 January 2016 Accepted 22 February 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Thyroid hemiagenesis is a rare congenital anomaly that is caused by a developmental defect of a thyroid. Previous reports indicate that thyroid cancer associated with hemiagenesis is extremely rare. A 47-year-old woman presented with single nodule in the right thyroid gland that was incidentally detected during a routine medical checkup. Ultrasonography showed a 1.5×1.2 cm sized ill-defined irregular hypoehoic nodule in the right thyroid and the isthmus was present. However, the left thyroid was not seen and thyroid was disconnected at left paraisthmic area. Fine-needle aspiration cytology confirmed that the right thyroid nodule was papillary thyroid carcinoma. Total thyroidectomy with bilateral central compartment node dissection was performed. Permanent pathologic finding was 1.3×1 cm sized classical type papillary thyroid carcinoma with nodular hyperplasia. There was extensive lymphatic invasion and 3 metastatic lymph nodes out of 4 in central compartment. In conclusion, although thyroid hemiagenesis associated with thyroid carcinoma is extremely rare, treatment strategy is not different with patients with normal anatomy. And the possibility of developing a thyroid carcinoma should be considered in patients with hemiagenesis. Furthermore, it requires awareness of anatomical difference around the thyroid gland during operation.

Keywords: Thyroid hemiagenesis, Thyroid cancer, Papillary thyroid carcinoma

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Fig. 1.

Ultrasonography of the thyroid gland showing one hypoechoic nodule (arrow) in the right thyroid (A) and no thyroid tissue in the left thyroid (B).

Fig. 2.

Operative finding of specimen showing absence of left lobe.

Table 1.

Thyroid hemiagenesis associated with thyroid cancer

Study	Age	Sex	Site of thyroid hemiagenesis	Thyroid tumor	Isthmus
Hanburger et al.¹⁴⁾	14	F	Left	PTC＋ FTC	Absent
Harada et al.¹⁵⁾	74	F	Right	PTC	Present
Greening et al.¹⁶⁾	51	F	Left	PTC	Absent
Khatri et al.¹¹⁾	41	F	Right	PTC	Present
McHenry et al.¹⁰⁾	58	F	Left	FTC	Present
Shaha et al.¹²⁾	30	F	Right	PTC	Present
Park et al.¹⁷⁾	43	F	Right	PTC	Unknown
Huang et al.⁸⁾	47	F	Right	PTC	Present
Pizzini et al.⁴⁾	54	M	Left	PTC	Present
Lee et al.³⁾	69	F	Left	PTC	Unknown
Kim et al.⁹⁾	56	F	Left	FTC	Present
Park et al.¹³⁾	29	F	Right	PTC	Present
Nam et al.¹⁸⁾	53	F	Right	PTC	Absent
Wang et al.⁵⁾	49	F	Right	MTC	Absent
	60	F	Left	PTC	Present
Karatag et al.¹⁹⁾	59	F	Left	PTC	Unknown
Campenni et al.²⁰⁾	36	M	Left	PTC	Absent
Park (present report)	47	F	Left	PTC	Present

FTC: follicular thyroid carcinoma, MTC: medullary thyroid carcinoma, PTC: papillary thyroid carcinoma

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