Hyponatremia after Radioactive Iodine Treatment in Thyroid Cancer Patients

Oh Chan Kwon; Hoon Hee Lee; Kyung Hwan Oh; Tae Yong Kim

doi:10.11106/ijt.2016.9.1.39

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Kwon, Lee, Oh, and Kim: Hyponatremia after Radioactive Iodine Treatment in Thyroid Cancer Patients

Case Report

Int J Thyroidol 2016;9(1):39-42.

Published online: 20 May 2016

DOI: https://doi.org/10.11106/ijt.2016.9.1.39

Hyponatremia after Radioactive Iodine Treatment in Thyroid Cancer Patients

Oh Chan Kwon, Hoon Hee Lee, Kyung Hwan Oh, Tae Yong Kim

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Correspondence: Tae Yong Kim, MD, PhD, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea Tel: 82-2-3010-6962, Fax: 82-2-3010-3249, E-mail: tykim@amc.seoul.kr

Received 16 December 2015 Revised 23 February 2016 Accepted 7 March 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Radioactive iodine treatment (RAIT) after surgery reduces local recurrence and cancer related death. Cases of hyponatremia after preparation for RAIT have rarely been reported. We report 4 cases of hyponatremia which developed after RAIT. The cause of hyponatremia seemed to be related with over ingestion of free water which is recommended during RAIT. These cases highlighted the importance of weight adjusted water ingestion during RAIT.

Keywords: Thyroid neoplasms, Iodine radioisotopes, Hyponatremia, Water intoxication

References

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Table 1.

Patient characteristics

Patient	Age/sex	Plasma sodium before RAIT (mEq/L)	TSH (microU/mL)	Thiazide	Serum osmolarity (mosm/kg)	Urine osmolarity (mosm/kg)	Urine sodium (mmol/L)	RAIT preperation method
1	58/F	140	＞77	Yes	Not checked	Not checked	Not checked	Hormone withdrawal
2	59/F	142	＞77	No	244	227	90	Hormone withdrawal
3	71/F	143	＞77	Yes	268	360	101	Thyrogen
4	56/F	139	＞77	No	Not checked	Not checked	Not checked	Hormone withdrawal

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