Journal List > Int J Thyroidol > v.10(1) > 1082704

Seo, Kim, and Woo: A Case of Hyalinizing Trabecular Adenoma of the Thyroid Gland


Hyalinizing trabecular adenoma of the thyroid gland is a rare benign neoplasm. It is characterized by an encapsulated nodule, trabecular arrangement of polygonal, oval, elongated cells, and hyalinized stroma. It is easily confused with medullary thyroid carcinoma or papillary thyroid carcinoma. Distinguishment with pathologic finding and immunohistochemical studies are needed to make a definite diagnosis. We recently experienced a case of hyalinizing trabecular adenoma of the thyroid gland. A 73-year-old woman present with an incidentally detected left thyroid mass. Fine needle aspiration was performed and papillary thyroid carcinoma was suspected. However, the surgical specimen revealed a hyalinizing trabecular adenoma. We present this case with a review of the literature.

Figures and Tables

Fig. 1

Ultrasonographic evaluation shows 1.25×1.46 cm sized nodule with marked hypoechoic and suspicious internal calcification (A) and 1.02×0.67 cm sized nodule with internal calcification (B) in left lower thyroid.

Fig. 2

Fine needle aspiration cytology shows cluster of atypical follicular cells and variable sized nucleus with intranuclear pseudo-inclusions (H&E staining, ×400).

Fig. 3

H&E staining and immunochemistry findings. (A) Tumor cells with intranuclear pseudo-inclusion are arranged in trabecular pattern separated by stroma, which is markedly hyalinized (H&E staining, ×400), (B) This photograph shows negative for cytokeratin 19 (cytokeratin 19 immunostaining, ×400), (C) This photograph shows negative for Ki-67 (Ki-67 immunostaining, ×400), (D) This photograph shows negative for galactin-3 (galactin-3 immunostaining, ×200), (E) This photograph shows positive for CD56 (CD56 immunostaining, ×200).



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