A Case of Hyalinizing Trabecular Adenoma of the Thyroid Gland

Jin Hyun Seo; Jin Pyeong Kim; Seung Hoon Woo

doi:10.11106/ijt.2017.10.1.46

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Seo, Kim, and Woo: A Case of Hyalinizing Trabecular Adenoma of the Thyroid Gland

Case Report

International Journal of Thyroidology 2017; 10(1): 46-49.

Published online: 26 May 2017

DOI: https://doi.org/10.11106/ijt.2017.10.1.46

A Case of Hyalinizing Trabecular Adenoma of the Thyroid Gland

Jin Hyun Seo¹, Jin Pyeong Kim¹, Seung Hoon Woo^1,²

¹Department of Otolaryngology, Gyeongsang National University, Jinju, Korea.

²Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.

Correspondence: Seung Hoon Woo, MD, Department of Otorhinolaryngology, Gyeongsang National University, 79 Gangnam-ro, Jinju 52727, Korea. Tel: 82-55-750-8173, Fax: 82-55-759-0613, lesaby@hanmail.net

Received 17 November 2016 Revised 22 February 2017 Accepted 9 March 2017

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyalinizing trabecular adenoma of the thyroid gland is a rare benign neoplasm. It is characterized by an encapsulated nodule, trabecular arrangement of polygonal, oval, elongated cells, and hyalinized stroma. It is easily confused with medullary thyroid carcinoma or papillary thyroid carcinoma. Distinguishment with pathologic finding and immunohistochemical studies are needed to make a definite diagnosis. We recently experienced a case of hyalinizing trabecular adenoma of the thyroid gland. A 73-year-old woman present with an incidentally detected left thyroid mass. Fine needle aspiration was performed and papillary thyroid carcinoma was suspected. However, the surgical specimen revealed a hyalinizing trabecular adenoma. We present this case with a review of the literature.

Keywords: Hyalinizing trabecular adenoma, Papillary thyroid cancer, Medullary thyroid cancer

Figures and Tables

Fig. 1

Ultrasonographic evaluation shows 1.25×1.46 cm sized nodule with marked hypoechoic and suspicious internal calcification (A) and 1.02×0.67 cm sized nodule with internal calcification (B) in left lower thyroid.

Fig. 2

Fine needle aspiration cytology shows cluster of atypical follicular cells and variable sized nucleus with intranuclear pseudo-inclusions (H&E staining, ×400).

Fig. 3

H&E staining and immunochemistry findings. (A) Tumor cells with intranuclear pseudo-inclusion are arranged in trabecular pattern separated by stroma, which is markedly hyalinized (H&E staining, ×400), (B) This photograph shows negative for cytokeratin 19 (cytokeratin 19 immunostaining, ×400), (C) This photograph shows negative for Ki-67 (Ki-67 immunostaining, ×400), (D) This photograph shows negative for galactin-3 (galactin-3 immunostaining, ×200), (E) This photograph shows positive for CD56 (CD56 immunostaining, ×200).

References

1. Carney JA, Ryan J, Goellner JR. Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol. 1987; 11(8):583–591.

2. Lee HK, Kim HS, Hur MH, Kang SS, Lee JH, Lee SK. Hyalinizing trabecular adenoma of thyroid gland. J Korean Surg Soc. 2002; 62(1):87–90.

3. Yim HE, Shim C, Soh EY. Hyalinizing trabecular adenoma of the thyroid: a case report. Korean J Pathol. 1998; 32(3):226–230.

4. Nose V, Volante M, Papotti M. Hyalinizing trabecular tumor of the thyroid: an update. Endocr Pathol. 2008; 19(1):1–8.

5. Jang KY, Kim JH, Chung MJ, Moon WS, Kang MJ. Hyalinizing trabecular carcinoma of the thyroid gland: a report of two cases. Korean J Pathol. 2000; 34(4):318–322.

6. Park KS, Kim SW, Min HS, Han WS, Noh DY, Park SH, et al. Hyalinizing trabecular adenoma of thyroid. J Korean Surg Soc. 2003; 65(6):572–575.

7. Casey MB, Sebo TJ, Carney JA. Hyalinizing trabecular adenoma of the thyroid gland identification through MIB-1 staining of fine-needle aspiration biopsy smears. Am J Clin Pathol. 2004; 122(4):506–510.

8. Hirokawa M, Carney JA, Ohtsuki Y. Hyalinizing trabecular adenoma and papillary carcinoma of the thyroid gland express different cytokeratin patterns. Am J Surg Pathol. 2000; 24(6):877–881.

9. Bishop JA, Ali SZ. Hyalinizing trabecular adenoma of the thyroid gland. Diagn Cytopathol. 2011; 39(4):306–310.

10. LaGuette J, Matias-Guiu X, Rosai J. Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. Am J Surg Pathol. 1997; 21(7):748–753.

11. Salvatore G, Chiappetta G, Nikiforov YE, Decaussin-Petrucci M, Fusco A, Carney JA, et al. Molecular profile of hyalinizing trabecular tumours of the thyroid: high prevalence of RET/PTC rearrangements and absence of B-raf and N-ras point mutations. Eur J Cancer. 2005; 41(5):816–821.

12. Kuma S, Hirokawa M, Miyauchi A, Kakudo K, Katayama S. Cytologic features of hyalinizing trabecular adenoma of the thyroid. Acta Cytol. 2003; 47(3):399–404.

13. Sung SY, Shen HY, Hsieh CB, Duh QY, Su TF, Chan DC, et al. Hyalinizing trabecular tumor of thyroid: does frozen section prevent unnecessarily aggressive operation? Six new cases and a literature review. J Chin Med Assoc. 2014; 77(11):573–577.

14. Sambade C, Franssila K, Cameselle-Teijeiro J, Nesland J, Sobrinho-Simoes M. Hyalinizing trabecular adenoma: a misnomer for a peculiar tumor of the thyroid gland. Endocr Pathol. 1991; 2(2):83–91.

15. Gowrishankar S, Pai SA, Carney JA. Hyalinizing trabecular carcinoma of the thyroid gland. Histopathology. 2008; 52(4):529–531.

16. Carney JA, Hirokawa M, Lloyd RV, Papotti M, Sebo TJ. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 2008; 32(12):1877–1889.

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