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Holford: Absorption and Half-Life
Original Article

Translational and Clinical Pharmacology 2016;24(4):157-160.

Published online: 19 January 2016

DOI: https://doi.org/10.12793/tcp.2016.24.4.157

Absorption and Half-Life

Nick Holford

Department of Pharmacology & Clinical Pharmacology, University of Auckland, Auckland, New Zealand

∗Correspondence: Nick Holford; Tel: +64-9-923-6730, E-mail: n.holford@auckland.ac.nz

Copyright © 2016 Korean Society for Clinical Pharmacology and Therapeutics

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This tutorial deals with basic concepts of absorption processes and links previous tutorials on clearance and volume of distribution to introduce the concept of half-life. The time course of both absorption and elimination are commonly described using a half-life. Half-life can also be used to describe drug accumulation. Understanding the principles underlying the time course of absorption and elimination are essential in pharmacotherapy and clinical pharmacology.

Keywords: absorption, half-life, pharmacokinetics, clinical pharmacology

Figure 1
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Figure 2
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Figure 3
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Figure 4
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Table 1.
Time % Css Concentration
0 0 100
1 50 50
2 75 25
3 87.5 12.5
4 93.8 6.25
5 96.9 3.1
6 98.4 1.6
7 99.2 0.8
8 99.6 0.4
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