Dong-Seok Yim

doi:10.12793/tcp.2015.23.2.35

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Yim: “Physiological spaces and multicompartmental pharmacokinetic models”: Fundamentals that pharmacokinetics textbooks do not tell you

Original Article

Translational and Clinical Pharmacology 2015;23(2):35-37.

Published online: 15 December 2015

DOI: https://doi.org/10.12793/tcp.2015.23.2.35

“Physiological spaces and multicompartmental pharmacokinetic models”: Fundamentals that pharmacokinetics textbooks do not tell you

Dong-Seok Yim^∗

Department of Clinical Pharmacology and Therapeutics, Seoul St. Mary's Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, The Catholic University of Korea, Seoul 06591, Korea

^∗Correspondence: D. S. Yim; Tel: +82-2-2258-7327, Fax: +82-2-2258-7876, E-mail: yimds@catholic.ac.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

1. Atkinson AJ Jr. Physiological spaces and multicompartmental pharmacokinetic models. Transl Clin Pharmacol. 2015; 23:35–37.

2. Paalzow LK. Torsten Teorell, the father of pharmacokinetics. Uppsala J Med Sci. 1995; 100:41–46.

3. Bowsher DJ, Avram MJ, Frederiksen MC, Asada A, Atkinson AJ Jr. Urea distribution kinetics analyzed by the simultaneous injection of urea and inulin: Demonstration that transcapillary exchange is rate limiting. J Pharmacol ExpTher. 1984; 230:269–274.

4. Bohr C. Über die spezifische Tätigkeit der Lungenbei der respiratorischen Gasaufnahme und ihr Verhaltenzu der durch die Alveolarwandstattfinden-den Gasdiffusion. Skand Arch Physiol. 1909; 22:221–280.

5. West JB. A Century of Pulmonary Gas Exchange. Am J Respir Crit Care Med. 2004; 169:897–902.

6. Kety S. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951; 3:1–41.

7. Elsenberg L. Obituary: Seymour S. Kety (1915–2000). Nature. 2000; 406:472.

8. Renkin EM. Effects of blood flow on diffusion kinetics in isolated perfused hindlegs of cats: a double circulation hypothesis. Am J Physiol. 1955; 183:125–136.

9. Stec GP, Atkinson AJ Jr. Analysis of the contributions of permeability and flow to intercompartmental clearance. J Pharmacokinet Biopharm. 1981; 9:167–180.

10. Sedek GS, Ruo TI, Frederiksen MC, Frederiksen JW, Shih S-R, Atkinson AJ Jr. Splanchnic tissues are a major part of the rapid distribution spaces of inulin, urea and theophylline. J Pharmacol Exp Ther. 1989; 251:1026–1031.

11. Bowsher DJ, Krejcie TC, Avram MJ, Chow MJ, Del Greco F, Atkinson AJ Jr. Reduction in slow intercompartmental clearance of urea during dialysis. J Lab Clin Med. 1985; 105:489–497.

Figure 1.

Key historical figures who contributed to the permeability-flow equation (Renkin equation).

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