Ji-Young Park; Yu-Jung Cha; Kyoung-Ah Kim

doi:10.12793/tcp.2014.22.1.3

Journal List > Transl Clin Pharmacol > v.22(1) > 1082589

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Park, Cha, and Kim: CYP3A5∗3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role

Original Article

Translational and Clinical Pharmacology 2014;22(1):3-7.

Published online: 30 June 2014

DOI: https://doi.org/10.12793/tcp.2014.22.1.3

CYP3A5∗3 Polymorphism and Its Clinical Implications and Pharmacokinetic Role

Ji-Young Park^∗, Yu-Jung Cha, Kyoung-Ah Kim

Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, Seoul 136–705, Korea

^∗Correspondence: J. Y. Park; Tel: +82-2-920-6288, Fax: +82-2-929-3279, E-mail: jypark21@korea.ac.kr

Received 23 April 2014 Accepted 23 April 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cytochrome P450 (CYP) 3A subfamily is estimated to participate in the biotransformation of 50% of the currently prescribed drugs. Four members of the CYP3A subfamily have been identified in humans: CYP3A4, CYP3A5, CYP3A7, and CYP3A43. Initial data suggested that CYP3A5 accounts for only a small proportion of the total hepatic CYP3A in about 20% of samples, but it was later revealed that CYP3A5 represents more than 50% of the total CYP3A amount in some individuals. Several genetic variants have been described for the CYP3A5 gene, of which the CYP3A5∗3 allele (gA6986G), the most common form and leading to the loss of CYP3A5 activity, has been extensively investigated in the aspect of pharmacokinetics and disease risk. This review summarized the molecular characteristics of the CYP3A5 gene, and discusses the association of the CYP3A5∗3 polymorphism with disease risks such as cancer and hypertension, along with its role in the pharmacokinetics of CYP3A substrates.

Keywords: CYP3A5∗3, Cytochrome P450, Cancer, Pharmacokinetics, Pharmacogenetics

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