Animal Experiment of Legg-Calve-Perthes Disease in Piglets, Puppies and Growing Rabbits

Sung-Man Rowe

doi:10.5371/hp.2012.24.4.265

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Rowe: Animal Experiment of Legg-Calve-Perthes Disease in Piglets, Puppies and Growing Rabbits

Editorial

Hip & Pelvis

Hip & Pelvis 2012; 24(4): 265-272.

Published online: 31 December 2012

DOI: https://doi.org/10.5371/hp.2012.24.4.265

Animal Experiment of Legg-Calve-Perthes Disease in Piglets, Puppies and Growing Rabbits

Sung-Man Rowe, MD, PhD

Department of Orthopedic Surgery, Chonnam National University Hwasun Geriatric Hospital, Jeonnam, Korea.

Address reprint request to Sung-Man Rowe, MD, PhD. Department of Orthopedic Surgery, Chonnam National University Hwasun Geriatric Hospital, 160 Ilsim-ri, Hwasun-eup, Hwasun-gun, Jeonnam 519-809, Korea. TEL: +82-61-379-7676, FAX: +82-61-379-7681, smrowe@chonnam.ac.kr

Received 7 November 2012 Revised 20 December 2012 Accepted 21 December 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Figures and Tables

Fig. 1

(A-C) Photographs of animal models of LCPD in piglets, puppies, and growing rabbits.

Fig. 2

(A-D) Composite radiographic findings from extracted femurs from a piglets sacrificed at postoperative week 4 (A), 8 (B), 12 (C), and 16 (D) showing gradual increase of coxa plana, coxa magna, and greater trochanter overgrowths.

Fig. 3

(A) Radiography of the extractred femurs from a puppy of Group C at postoperative two months showing a decrease in epiphyseal height and cystic changes of the ossific nucleus at left operated femur. (B) Macroscopic photography showing shortening of 2.5 mm with a mild degree of medial bowing of the femoral neck at left operated femur. (C-D) Macroscopic appearances of both extracted femurs five months after operation showing remarkable increase in anteversion and coxa magna of the operated left femur.

Fig. 4

(A) Radiograph before surgery showing normal hip of 5 week-year-old rabbit. (B) Radiograph at postoperative 4 weeks showing coxa vara and greater trochanter (GT) overgrowth. (C) Radiograph at 12 weeks showing further increase of deformities. (D) Macroscopic finding of extracted femur showing coxa magna, coxa vara, and GT overgrowth.

Table 1

Piglet Groups according to Postoperative Periods

Table 2

Macroscopical and Radiological Changes of the Femoral Head in 26 Piglets with Vascular Infarct

^*Rs: Spearman's Correlation Coefficient.

Table 3

Puppy Groups according to Extent of Surgery and Postoperative Duration

Table 4

Macroscopic, Radiologic and Microscopic Examinations of the Femoral Head and Neck

Table 5

Presence (+) or Absence (-) of Abnormal Findings of the Femoral Head and Neck in Three Experimental Groups in Puppy Model

Table 6

Rabbit Groups according to the Vascular Interruption and the Cast Immobilization of the Knee

Table 7

Radiological and Macroscopic Abnormalities

Table 8

Mean Head Deformity Score (HDS) after Procedures in Experimental Groups

^*Numbers in parentheses are sample sizes.

Table 9

Distribution of 10 Hips Showing Severe Collapse of Femoral Head and Neck in Experimental Groups

^*N: Number.

Table 10

Head Deformity Scores (HDS) and Number of Severe Collapse of Femoral Head and Neck in 20 Rabbits Devascularized (Both Group A and B) and Sacrificed at 8 and 12 Weeks

P=0.006, γ=0.863.

^*N: Number.

References

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