Effect of Intravenous Administration of Bisphosphonate for Patients Operatively Treated for Osteoporotic Hip Fracture

Sang Hong Lee; Woong Chae Na; Yi Kyu Park

doi:10.5371/hp.2012.24.2.133

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Lee, Na, and Park: Effect of Intravenous Administration of Bisphosphonate for Patients Operatively Treated for Osteoporotic Hip Fracture

Original Article

Hip & Pelvis

Hip & Pelvis 2012; 24(2): 133-138.

Published online: 30 June 2012

DOI: https://doi.org/10.5371/hp.2012.24.2.133

Effect of Intravenous Administration of Bisphosphonate for Patients Operatively Treated for Osteoporotic Hip Fracture

Sang Hong Lee, MD, Woong Chae Na, MD, Yi Kyu Park, MD

Department of Orthopaedic Surgery, College of Medicine, Chosun University, Gwangju, Korea.

Address reprint request to Sang Hong Lee, MD. Department of Orthopaedic Surgery, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 501-717, Korea. TEL: +82-62-220-3147, FAX: +82-62-226-3379, shalee@chosun.ac.kr

Received 4 January 2012 Revised 12 June 2012 Accepted 12 June 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We evaluated changes in bone mineral density and biochemical bone turn over markers resulting from intravenous administration of zoledronic acid for the purpose of increasing bone mineral density and decreasing bone turnover rate in patients who had received operative treatment after hip fracture.

Materials and Methods

We carried out a retrospective study of 34 patients who had received injections of zoledronic acid after surgical treatment for hip fracture from January 2009 to June 2010, with a follow up period of more than one year. We evaluated pre and post T-scores of DXA in spine, proximal femur and femoral neck along with biochemical bone metabolic markers, and we then analyzed each factor.

Results

T score was enhanced in all cases with pre T-score -4.2 and post T-score -3.3 revealing statistical significance (P<0.05). In addition, two biochemical bone turnover markers were observed to decrease in most patients. Three days after drug administration, 7 patients(20.6%) had minor adverse effects. There were no serious complications such as atrial fibrillation.

Conclusion

No major adverse effects were observed, only minor ones in patients who had been injected with zoledronic acid for the prevention of osteoporotic fracture after surgical treatment for hip fracture. We confirmed the affirmative effects on changes in bone mineral density and biochemical bone turn over markers associated with the use of this drug.

Keywords: Hip fracture, Osteoporosis, Zoledronic acid

Figures and Tables

Fig. 1

Changes in bone mineral density.

Fig. 2

Changes in biochemical bone metabolic marker: Bone-specific alkaline phosphatase (BAC), C-telopeptide of type I collagen (CTx). (Normal range: CTx: 40-465 pg/ml, BAP: 40-120 IU/L).

Table 1

Adverse Events

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