Differential Diagnosis between Hand-foot Syndrome and Gout in Colorectal Cancer with Capecitabine: A Case Study and Review of the Literature

Jeong Yun Park

doi:10.5388/aon.2014.14.1.1

Journal List > Asian Oncol Nurs > v.14(1) > 1081799

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Park: Differential Diagnosis between Hand-foot Syndrome and Gout in Colorectal Cancer with Capecitabine: A Case Study and Review of the Literature

Review Article

Asian Oncology Nursing 2014; 14(1): 1-6.

Published online: 31 March 2014

DOI: https://doi.org/10.5388/aon.2014.14.1.1

Differential Diagnosis between Hand-foot Syndrome and Gout in Colorectal Cancer with Capecitabine: A Case Study and Review of the Literature

Jeong Yun Park

Department of Clinical Nursing, University of Ulsan, Seoul, Korea.

Address reprint requests to: Park, Jeong Yun. Department of Clinical Nursing, University of Ulsan, 86 Asanbyeongwon-gil, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-5333 Fax: +82-2-3010-5332, pjyun@ulsan.ac.kr

Received 16 January 2014 Accepted 26 March 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study is to present a case of a patient experiencing foot pain after being prescribed capecitabine and to review the differential diagnosis between hand-foot syndrome and gout.

Methods

This case is an 89-year-old patient endorsed to an emergency department with a 2-day history of foot swelling and pain.

Results

The old patient was treated with capecitabine which was orally administered twice daily for 2 weeks, followed by 1 week of rest. He experienced severe pain in his foot area during the 3rd chemotherapy cycle. Side effects must be assessed to keep treatment on course.

Conclusion

Clinical specialists should be knowledgeable of differential diagnosis.

Keywords: Colorectal Cancer, Elderly, Hand-Foot Syndrome, Gout, Capecitabine

Figures and Tables

Fig. 1

Patient-reported symptom. Erythema, Pain, and Edema of the Foot.

Table 1

National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE)

ADLs=activities of daily living.

Source=Yarbro CH, Wujcik D, Gobel BH. Cancer symptom management. Jones & Bartlett Learning; 2014.

Table 2

Recommendations for Prevention of Hand-Foot Syndrome

Source=Yarbro CH, Wujcik D, Gobel BH. Cancer symptom management. Jones & Bartlett Learning; 2014.

References

1. Hong YS, Kim TW. Chemotherapy for colorectal cancer. J Korean Med Assoc. 2010; 53(7):582–591.

2. Jung JM, Jung SA, Kim SE, Kang MJ, Shim KN, Kim KH, et al. Factors favoring survival in elderly patients with colorectal cancer. Korean J Med. 2009; 76(6):701–712.

3. Neuman HB, O'Connor ES, Weiss J, LoConte NK, Greenblatt DY, Greenberg CC, et al. Surgical treatment of colon cancer in patients aged 80 years and older. Cancer. 2013; 119(3):639–647.

4. Yarbro CH, Wujcik D, Gobel BH. Cancer symptom management. MA: Jones & Bartlett Learning;2014.

5. Abushullaih S, Saad ED, Munsell M, Hoff PM. Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience. Cancer Invest. 2002; 20(1):3–10.

6. U.S. Department of Health and Human Services. Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. National Cancer Institute No. 09-5410. 2009.

7. Song SJ. Clinical Manifestations and Diagnosis of Gout. J Korean Med Assoc. 2010; 53(8):695–704.

8. Seo YI, Son KM, Jung YO, Kim IJ, Kim KL, Bae YD, et al. Survey of current trends for diagnosis and treatment in Korean gout patients. J Rheum Dis. 2011; 18(3):187–192.

TOOLS

Similar articles