Journal List > J Nutr Health > v.48(1) > 1081385

J Nutr Health. 2015 Feb;48(1):19-29. Korean.
Published online February 28, 2015.  https://doi.org/10.4163/jnh.2015.48.1.19
© 2015 The Korean Nutrition Society
Effect of xylooligosaccharide-sugar mixture on defecation frequency and symptoms in young women with constipation: a randomized, double-blind, placebo-controlled trial
Jin Ho Jeon,1 Myungok Kyung,2 Sangwon Jung,2 SungEun Jo,2 and Moon-Jeong Chang1
1Department of Food and Nutrition, Kookmin University, Seoul 136-706, Korea.
2R&D Center, TS Corporation, Incheon 400-201, Korea.

To whom correspondence should be addressed. tel: +82-2-910-4776, Email: cmoon@kookmin.ac.kr
Received December 29, 2014; Revised January 14, 2015; Accepted January 26, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Purpose

To investigate the effects of the intake of xylooligosaccharide-sugar mixture (XOS) on defecation frequency and symptoms in 56 young women (mean age of 22.1 years old) with constipation.

Methods

Two experiments were conducted. In experiment 1, a randomized double-blind study was performed to evaluate the effect of 6 weeks' intake of 10 g sucrose containing 7% xylooligosaccharide or 10 g sucrose on constipation. In experiment 2, 24 g coffee mixture containing 12.8 g plant cream and 11.2 g xylooligosaccharide-sugar mixture was consumed by the subjects. During the study, the clinical efficacy was assessed by using a daily diary. The subjects indicated the number of frequencies they defecated in a day and the clinical symptom scores.

Results

In experiment 1, the mean frequency of defecations was 2.07 in the pretreatment week and increased significantly to 4.05, 4.42, 4.84, 4.84, and 4.05 in weeks 2 to 6 of XOS intake, in comparison with the 3-3.67 with sucrose intake (sucrose, SUC). In experiment 2, the mean frequency of defecations significantly increased from 2.47 in the pretreatment week to 4.11-5.67 in weeks 1-6 of XOS intake. The occurrence of very loose or loose stools in the XOS group was significantly increased in weeks 5 and 6, compared with the pretreatment week and SUC group. XOS intake significantly alleviated the abdominal displeasure and feeling of residual stool leftness in weeks 2, 3, 5, and 6, while SUC did so in weeks 4 and 6 (p < 0.05). The coffee mixture containing xylooligosaccharide-sugar mixture reduced the abdominal displeasure and feeling of residual stool leftness from week 3 until the end of the experiment (p < 0.05).

Conclusion

Our results suggest that xylooligosaccharide-sugar mixture intake was effective, without adverse effects, for the alleviation of constipation in the young women in this study.

Keywords: xylooligosaccharide; constipation; defecation frequency; young women

Figures


Fig. 1
The effect of xylooligosaccharide-sugar mixture intake on the bowl movement frequency of the subjects. A: Weekly transition of the mean frequency of stools of the subjects. B: Weekly transition of the number of days with defecation of the subjects. *Significant difference between XOS and SUC groups at p < 0.05. XOS: Xylooligosaccharide containing sugar mixture group, SUC: sugar group.
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Fig. 2
The effect of xylooligosaccharide-sugar mixture intake on the stool state of the subjects. A: Weekly transition of the subjective amount of stool. B: Weekly transition of the color of stool. C: Weekly transition of the stool consistency. Significant difference from the pre treatment, p < 0.05. *Significant difference between XOS group and SUC group at the same week, p < 0.05. XOS: Xylooligosaccharide-sugar mixture group, SUC: sugar group.
Click for larger image


Fig. 3
The effect of xylooligosaccharide-sugar mixture intake on abdominal state of the subjects. A: Weekly transition of the feeling of abdominal displeasure. B: Weekly transition of the feeling of residual stool leftness. Significant difference from the pre treatment, p < 0.05. XOS: Xylooligosaccharide-sugar mixture group, SUC: sugar group.
Click for larger image


Fig. 4
The effect of xylooligosaccharide-sugar mixture containing coffee mix intake on the bowel movement frequency of the subject. A: Weekly transition of the mean number of stools of the subjects. B: Weekly transition of the number of days with defecation of the subjects. Significant difference from the pre treatment, p < 0.05.
Click for larger image


Fig. 5
The effect of xylooligosaccharide-sugar mixture containing coffee mix intake on abdominal state of the subjects. A: Weekly transition of the feeling of abdominal displeasure. B: Weekly transition of the feeling of residual stool leftness. *Significant difference from the pre treatment, p < 0.05.
Click for larger image

Tables


Table 1
General characteristics and defecation state of pretreatment stage in subjects
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Table 2
The weekly transition of evacuation time of stool (min)
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Table 3
The weekly transition of evacuation time of stool (min)
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Notes

This research was supported by High Value-added Food Technology Development Program (Project number: 313024-03-1-CG000), Ministry for Food, Agriculture, Forestry, Republic of Korea.

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