Jin Ho Jeon; Myungok Kyung; Sangwon Jung; SungEun Jo; Moon-Jeong Chang

doi:10.4163/jnh.2015.48.1.19

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Jeon, Kyung, Jung, Jo, and Chang: Effect of xylooligosaccharide-sugar mixture on defecation frequency and symptoms in young women with constipation: a randomized, double-blind, placebo-controlled trial∗

Research Article

J Nutr Health 2015;48(1):19-29.

Published online: 19 January 2015

DOI: https://doi.org/10.4163/jnh.2015.48.1.19

Effect of xylooligosaccharide-sugar mixture on defecation frequency and symptoms in young women with constipation: a randomized, double-blind, placebo-controlled trial^∗

Jin Ho Jeon¹, Myungok Kyung², Sangwon Jung², SungEun Jo², Moon-Jeong Chang^1,^†

¹Department of Food and Nutrition, Kookmin University, Seoul 136-706, Korea

²R&D Center, TS Corporation, Incheon 400-201, Korea

^†To whom correspondence should be addressed. tel: +82-2-910-4776, e-mail: cmoon@kookmin.ac.kr

^∗ This research was supported by High Value-added Food Technology Development Program (Project number: 313024-03-1-CG000),

Received 29 December 2014 Revised 14 January 2015 Accepted 26 January 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose:

To investigate the effects of the intake of xylooligosaccharide-sugar mixture (XOS) on defecation frequency and symptoms in 56 young women (mean age of 22.1 years old) with constipation.

Methods:

Two experiments were conducted. In experiment 1, a randomized double-blind study was performed to evaluate the effect of 6 weeks' intake of 10 g sucrose containing 7% xylooligosaccharide or 10 g sucrose on constipation. In experiment 2, 24 g coffee mixture containing 12.8 g plant cream and 11.2 g xylooligosaccharide-sugar mixture was consumed by the subjects. During the study, the clinical efficacy was assessed by using a daily diary. The subjects indicated the number of frequencies they defecated in a day and the clinical symptom scores.

Results:

In experiment 1, the mean frequency of defecations was 2.07 in the pretreatment week and increased significantly to 4.05, 4.42, 4.84, 4.84, and 4.05 in weeks 2 to 6 of XOS intake, in comparison with the 3-3.67 with sucrose intake (sucrose, SUC). In experiment 2, the mean frequency of defecations significantly increased from 2.47 in the pretreatment week to 4.11-5.67 in weeks 1-6 of XOS intake. The occurrence of very loose or loose stools in the XOS group was significantly increased in weeks 5 and 6, compared with the pretreatment week and SUC group. XOS intake significantly alleviated the abdominal displeasure and feeling of residual stool leftness in weeks 2, 3, 5, and 6, while SUC did so in weeks 4 and 6 (p < 0.05). The coffee mixture containing xylooligosaccharide-sugar mixture reduced the abdominal displeasure and feeling of residual stool leftness from week 3 until the end of the experiment (p < 0.05).

Conclusion:

Our results suggest that xylooligosaccharide-sugar mixture intake was effective, without adverse effects, for the alleviation of constipation in the young women in this study.

Keywords: xylooligosaccharide, constipation, defecation frequency, young women

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Fig. 1.

The effect of xylooligosaccharide -sugar mixture intake on the bowl movement frequency of the subjects. A: Weekly transition of the mean frequency of stools of the subjects. B: Weekly transition of the number of days with defecation of the subjects. ∗Significant difference between XOS and SUC groups at p < 0.05. XOS: Xylooligosaccharide containing sugar mixture group, SUC: sugar group.

Fig. 2.

The effect of xylooligosaccharide-sugar mixture intake on the stool state of the subjects. A: Weekly transition of the subjective amount of stool. B: Weekly transition of the color of stool. C: Weekly transition of the stool consistency. ^†Significant difference from the pre treatment, p < 0.05. ∗Significant difference between XOS group and SUC group at the same week, p < 0.05. XOS: Xylooligosaccha-ride-sugar mixture group, SUC: sugar group.

Fig. 3.

The effect of xylooligosaccharide- sugar mixture intake on abdominal state of the subjects. A: Weekly transition of the feeling of abdominal displeasure. B: Weekly transition of the feeling of residual stool leftness. ^†Significant difference from the pre treatment, p < 0.05. XOS: Xylooligosaccharide-sugar mixture group, SUC: sugar group.

Fig. 4.

The effect of xylooligosaccharide- sugar mixture containing coffee mix intake on the bowel movement frequency of the subject. A: Weekly transition of the mean number of stools of the subjects. B: Weekly transition of the number of days with defecation of the subjects. ^†Significant difference from the pre treatment, p < 0.05.

Fig. 5.

The effect of xylooligosaccharide- sugar mixture containing coffee mix intake on abdominal state of the subjects. A: Weekly transition of the feeling of abdominal displeasure. B: Weekly transition of the feeling of residual stool leftness. ∗Significant difference from the pre treatment, p < 0.05.

Table 1.

General characteristics and defecation state of pre treatment stage in subjects

Age (yr)	22.1 ± 2.4¹⁾
Height (cm)	161.9 ± 5.62
Body Weight (kg)	53.7 ± 5.91
The duration of constipation experience	6.07 ± 1.10
Stool frequency per week	2.32 ± 0.77
The use of laxatives (N, %)	7 (18.4%)
The use of alleviation of constipation (N, %)^∗	37 (66.1%)
Drinking water frequently	28 (50%)
Eating probiotics	27 (48.2%)
Eating vegetables and fruits frequently	14 (25.0%)

¹⁾ Mean±SD

^∗ Multiple responses

Table 2.

The weekly transition of evacuation time of stool (min)

	XOS¹⁾	SUC²⁾
pre	13.7 ± 1.1	16.0 ± 1.4
1 wk	12.4 ± 0.9	13.2 ± 0.9
2 wk	12.9 ± 1.1	15.3 ± 1.4⁴⁾∗
3 wk	11.7 ± 0.6³⁾	13.1 ± 1.2^†
4 wk	11.9 ± 0.9	14.5 ± 1.4
5 wk	11.9 ± 0.6	15.0 ± 1.3∗
6 wk	12.9 ± 1.1	14.1 ± 1.2

¹⁾ XOS: Xylooligosaccharide containing sugar group

²⁾ SUC: sugar group

³⁾ Significant difference from the pretreatment

⁴⁾ Significant difference between XOS group and SUC group at the same week.

Table 3.

The weekly transition of evacuation time of stool (min)

	XOSmix¹⁾
pre	12.9 ± 4.0
1 wk	11.7 ± 2.5
2 wk	11.4 ± 2.3
3 wk	11.7 ± 2.4
4 wk	11.4 ± 2.3
5 wk	11.1 ± 2.1
6 wk	11.1 ± 2.2

¹⁾ XOSmix: Xylooligosaccharide sugar containing coffee mix

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