In the last decade, temporary anchorage devices (TADs) have been merged into the mainstream of clinical orthodontic practice because of several advantages over the conventional anchorage approaches, including simple design of force delivery systems, reduced dependence on patient compliance, and expansion of the existing boundaries of tooth movements.1,2 Their success is affected by various patient factors such as age and the general healing capacity, inflammation status of the periimplant sites, quantity and quality of the cortical bone, and thickness and mobility of the soft tissue in the target areas.3-5

In the oral cavity, the palate is a popular sitefor TAD placement because of the thick keratinized masticatory mucosa, high accessibility, and reduced risk of root damage.6 Recently, several investigators have examined the adjacent areas of the midpalatal suture for use in TAD-assisted distalization mechanics in adolescents and adults.7,8

At present, several methods are available for evaluating the soft tissue thickness of the palate. The use of needles and periodontal probes has been documented since the 1970s.9,10 To avoid the need for local anesthesia, noninvasive techniques involving ultrasonic devices and computed tomography (CT) have also been studied.11-14 However, these approaches have been criticized for either questionable reliability or additional radiation risk.

On the other hand, the accuracy of cone-beam computed tomography (CBCT) for both soft tissue and bone thickness measurements in the maxillary anterior region has recently been confirmed, and a simple technique is now available for assessing the thickness of the palatal masticatory mucosa by CBCT.15-17 However, previous investigations with CBCT were limited to the buccal gingiva or palatal slope area, excluding the paramedian regions of the palate.16-18 Further, the soft tissue thickness at TAD placement sites in the palate at different ages has not been well documented in the literature.

The purposes of this investigation were to measure the palatal soft tissue thickness at popular placement sites of TADs by CBCT and evaluate the age, gender, and positional differences in this parameter.

The ICC coefficient of 0.976 and Bland-Altman plot revealed high intraexaminer assessment reliability (Figure 2).

The gender-based comparison revealed no significant difference (p = 0.124), although the female subjects tended to have thicker palatal soft tissue. Similarly, no significant difference was noted in the age-based comparison (p = 0.309). Interestingly, a significant qualitative interaction between age and the ML position (p = 0.006) was observed, indicating that the children had thicker palatal soft tissue laterally but thinner tissue medially than the adults (Table 1, Figure 3).

The analysis based on the measurement areas showed a significant effect of the ML position (p < 0.001) (Table 2, Figure 4): the lateral and sutural areas had the thickest and thinnest soft tissue, respectively. In contrast, no significant effect of the AP position was noted (p = 0.350) (Table 2). In addition, a significant interaction was observed between the ML and the AP positions (p = 0.011), as shown in Figure 4.

Various techniques are currently available to evaluate the palatal soft tissue thickness.10-17 For instance, Ueno et al.14 demonstrated a high correlation between spiral CT and physical measurements of the maxillary oral mucosa; however, they also recommended that spiral CT should not be used to measure the mucosal thickness alone because of higher radiation exposure. On the other hand, CBCT, which is widely used in contemporary orthodontic practice, ensures a significantly reduced radiation dose due to its lower output and shorter exposure time. Its potential drawbacks include higher image noise and lower contrast resolution from scattered radiation.20

CBCT has recently been applied for reliable measurement of the dentogingival soft tissue.15-17 Januário et al.15 and Barriviera et al.16 used plastic lip retractors and wooden spatulas to retract the soft tissue from the mucosal surface and obtain clear CBCT images. We took similar steps by excluding any scans in which the tongue contacted the roof of the mouth, so that no pressure was applied on the palatal surface and unambiguous measurements could be obtained.

According to our study, the soft tissue over the midpalatal suture was the thinnest, ranging from 1.22 to 1.35 mm, whereas that in the lateral area was the thickest, ranging from 2.51 to 3.00 mm (p < 0.001) (Table 2). Direct comparison with other investigations is somewhat difficult because of the difference in the reference structures. For example, Barriviera et al.16 reported that the mucosal thickness of the higher region of the palate, which may be physically related to the lateral area in our study, ranges from 3.13 to 4.51 mm. Although their slightly elevated data are still within the standard deviations determined in our study, differences in the measurement areas and ethnicity of the patients likely contribute to the discrepancy between the studies.

On the basis of CT images from 100 adult patients, Song et al.13 concluded that the soft tissue of the area over the palatal slope thickens posteriorly, and reported a range of 3.13 to 3.81 mm. However, we could not confirm this AP trend. The difference between their and our data may be explained by the fact that their measurement sites were located further away from the midpalatal suture, where even thicker tissue exists along the palatal slope, because their measurements were performed closer to their own reference structures such as the palatal gingival margins.

Kim et al.18 performed direct measurements of the soft tissue thickness in 23 adult cadavers and found that the thickness along the midpalatal suture stays relatively constant from 1.01 to 0.90 mm beginning 8 mm posterior to the incisive papilla. Consistent with their results, the soft tissue thickness over the suture was stable in our study, ranging from 1.22 to 1.35 mm (Table 2).

Considering age, Wara-aswapati et al.10 used a bone sounding method and discovered that older (mean, 38.7 ± 6.8 years) patients had thicker palatal masticatory mucosa than younger (mean, 16.8 ± 2.0 years) ones (p < 0.01). This difference was not reciprocated in our investigation (p = 0.967). This inconsistency, however, is in agreement with the findings of Eger et al.,11 who also reported no difference among age groups. Possible explanations for these conflicting reports are the difference in the measurement areas and the increased palatal soft tissue thickness in the areas of interest with age. In fact, Song et al.13 reported that the palatal masticatory mucosa is thicker in the age group of 41 to 60 years than in younger and older age groups, clarifying why our investigation did not reveal any significant difference between the children (mean age, 10.87 ± 1.24 years) and the adults (mean age, 21.35 ± 1.14 years).

In terms of gender, we found a general tendency for female subjects to have thicker palatal soft tissue. However, the absence of a significant gender difference (p = 0.491) is inconsistent with the findings of Song et al.13 and Müller et al.,12 who found thinner mucosal tissue in female subjects, but is consistent with those of Cha et al.21 and Wara-aswapati et al.,10 who reported no significant gender difference in the thickness. Many factors may have contributed to these conflicting results, such as differences in the ethnicity of the subjects, reference structures, and measurement techniques, all indicating the need of future investigations with larger sample sizes.

The stability of TADs in the palate depends on both the quantity and the quality of the soft and hard tissues.3,5 Therefore, for maximum retention and minimum inflammation, the desirable profile of a successful TAD placement site is thicker cortical bone underlying thinner attached gingival tissue. The most important finding of this investigation may be that the midpalatal suture and its adjacent areas have thinner soft tissue coverage regardless of gender, age, and the AP position. These results may help clinicians to select the appropriate TAD design, especially for the tissue collar or neck part, for better soft tissue adaptation, reduced inflammation, and greater success. However, they should be interpreted cautiously because of the substantial individual variations in the palatal soft tissue thickness.

CBCT may be a viable tool for assessing the soft tissue thickness in the anterior palatal region. Regardless of age and gender, the soft tissue thins toward the midpalatal suture. Therefore, clinical selection of TAD placement sites should be guided by knowledge of the positional variations in the palatal soft tissue thickness in addition to other contributing factors of TAD stability.