Journal List > J Korean Med Assoc > v.47(1) > 1080407

Lee: Diagnosis of Coronary Artery Disease Based on Cost-effectiveness Analysis

Abstract

Diagnostic strategies for coronary artery disease are diverse and include ① exercise EKG to coronary angiography, ② myocardial SPECT to coronary angiography, ③ dobutamine or exercise echocardiography to coronary angiography, and ④ direct coronary angiography. Cost-effectiveness analysis can be performed considering ① that the cost should include the costs of the diagnostic tests themselves, the cost of not-diagnosing the patients, the final test costs on false positive patients, and the cost to treat complications and ② that the effect should include quality-adjusted life year (QALY) with the fraction of proper diagnosis influenced by the diagnostic performance of the initial non-invasive tests. Based on the prior cost-effectiveness analysis, the pre-test likelihood affected most of the cost-effectiveness of a diagnostic strategy. Direct angiography was most cost-effective when the pre-test likelihood was high (>60%), while SPECT with or without a prior exercise EKG to angiography was most cost-effective when the pre-test likelihood was intermediate or low. Compared to stress echocardiography, stress myocardial SPECT was more cost-effective when the likelihood was moderate or high. While the prognostic significance of negative (including false-negative) cases was important to maintain cost-effectiveness of a strategy, myocardial SPECT to coronary angiography was the most cost-effective method to diagnose coronary artery disease.

Figures and Tables

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References

2. Lee DS, Jang MJ, Cheon GJ, Chung JK, Lee MC. Comparison of the cost-effectiveness of stress myocardial SPECT and stress echocardiography in suspected coronary artery disease considering the prognostic value of false-negative results. J Nucl Cardiol. 2002. 9:515–522.
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3. Patterson RE, Eisner RL, Horowitz SF. Comparison of cost-effectiveness and utility of exercise ECG, single photon emission computed tomography, positron emission tomography, and coronary angiography for diagnosis of coronary artery disease. Circulation. 1995. 91:54–65.
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