Nuclear Neurology

Sang Eun Kim

doi:10.5124/jkma.2003.46.3.175

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Kim: Nuclear Neurology

Special Issue

Recent Advances in Nuclear Medicine

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2003; 46(3): 175-179.

Published online: 31 March 2003

DOI: https://doi.org/10.5124/jkma.2003.46.3.175

Nuclear Neurology

Sang Eun Kim, M.D.

Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. sekim@smc.samsung.co.kr

(open-access):

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Functional brain imaging with single photon emission computed tomography (SPECT) and positron emission tomography (PET) enables the in vivo study of specific neurochemical processes in the context of normal regulatory mechanisms and pathophysiological alterations of the brain. Receptor studies with SPECT and PET have focused on the occupancy during drug treatment, quantification in neuropsychiatric diseases and visualization of specific pathology. SPECT and PET imaging of dopamine transporters can play an important role in detecting neuronal degeneration in parkinsonian syndromes and in drug-induced neurotoxicity. This article summarizes the SPECT and PET studies to evaluate the dopaminergic system in the human brain and their clinical applications.

Keywords: SPECT, PET, Dopamine

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References

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