Physicians need to be prepared with basic understandings of enuresis and practical tips to diagnose and treat the patients properly. The knowledge about the natural history, epidemiology, and etiology of enuresis, not to mention multiple treatment modalities available, are essential, Medical consultation and treatment of enuresis begins at the age of 5. Evaluation should include history taking, physical examination, and laboratory investigations. A checklist may be provided for quick evaluation in busy clinics. The two main treatment modalities are behavioral modification with an alarm system and pharmacotherapy with desmopressin or imipramine, or oxybutinin. The response to treatment is evaluated after a 1-to 3-months' period of treatment. further evaluation and individualized treatment are needed in poor responders. Normalization of a small functional bladder capacity may help to cure enuresis and treatment of enuresis with antibiotics is effective in children with urinary tract infection, bacteriuria, or cystitis cystica.