A Case of Chronic Gordonia otitidis Lung Infection Initially Regarded as Nontuberculous Mycobacterial Lung Disease

Hyerim Kim; Yun Seong Kim; Kye-Hyung Kim; Namhee Kim; Hyung Hoi Kim; Chulhun L. Chang; Jongyoun Yi

doi:10.5145/ACM.2017.20.1.13

Journal List > Ann Clin Microbiol > v.20(1) > 1078568

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Kim, Kim, Kim, Kim, Kim, Chang, and Yi: A Case of Chronic Gordonia otitidis Lung Infection Initially Regarded as Nontuberculous Mycobacterial Lung Disease

Original Article

Ann Clin Microbiol 2017;20(1):13-16.

Published online: 10 March 2017

DOI: https://doi.org/10.5145/ACM.2017.20.1.13

A Case of Chronic Gordonia otitidis Lung Infection Initially Regarded as Nontuberculous Mycobacterial Lung Disease

Hyerim Kim, Yun Seong Kim², Kye-Hyung Kim², Namhee Kim¹, Hyung Hoi Kim¹, Chulhun L. Chang¹, Jongyoun Yi¹

Departments of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea

¹Departments of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea

²Internal Medicine, Pusan National University School of Medicine, Busan, Korea

Correspondence: Jongyoun Yi, Department of Laboratory Medicine, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea. (Tel) 82-51-240-7417, (Fax) 82-51-240-7413, (E-mail) socioliberal@yahoo.co.kr Correspondence: Yun Seong Kim, Department of Internal Medicine, Pusan National University Yangsan Hospital, 20 Geumo-ro, Mulgeum-eup, Yangsan 50612, Korea. (Tel) 82-55-360-1414, (Fax) 82-55-360-1757, (E-mail) yskim@pusan.ac.kr

Received 29 December 2016 Revised 17 February 2017 Accepted 24 February 2017

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The genus Gordonia is one of the mycolic acid-con-taining aerobic actinomycetes. This genus has 38 named species that are widespread in the natural environment; however, Gordonia species rarely cause human infections. A 76-year-old woman presented with cough and sputum for over 1 year and was suspected of having nontuberculous mycobacterial (NTM) lung disease. An NTM isolate from the sputum was initially identified as Mycobacterium lentiflavum or Mycobacterium genavense by genotypic identification targeting internal transcribed spacer (ITS). However, the isolate was finally confirmed as Gordonia otitidis by sequencing of 16S rRNA, gyrB and secA1 genes. In patients with suspected NTM lung disease, the etiologic agent might be an organism other than NTM such as G. otitidis but still be identified as NTM without sequencing of 16S rRNA or other genes. Especially in case that a possible NTM isolate is identified as M. lentiflavum or M. genavense by the genotypic method targeting ITS, additional genotypic tests such as sequencing of 16S rRNA and other genes would be necessary for more reliable identification.

Keywords: Actinomycetales, Gordonia, Nontuberculous mycobacteria, Respiratory tract infections

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Fig. 1.

Phylogenetic trees based on 16S rRNA (A), gyrB (B), and secA1 (C) gene sequences showing the phylogenetic positions of the isolate from the present patient and related Gordonia and Mycobacterium species. The tree was constructed by the neighbor-joining method. Bootstrap values (from 1000 replications) are shown at branch points. The scale bar length of 0.01 indicates 1% sequence distance.

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