Two Cases of Medical Device-Related Corynebacterium striatum Infection: A Meningitis and A Sepsis

Yeung Chul Mun; Miae Lee; Sholhui Park; Hae-Sun Chung; Eui Kyo Seo; Yeung Chul Mun; Miae Lee

doi:10.5145/ACM.2021.19.1.28

Journal List > Ann Clin Microbiol > v.19(1) > 1078552

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Mun, Lee, Park, Chung, Seo, Mun, and Lee: Two Cases of Medical Device-Related Corynebacterium striatum Infection: A Meningitis and A Sepsis

Original Article

Ann Clin Microbiol 2016;19(1):28-31.

Published online: 12 March 2016

DOI: https://doi.org/10.5145/ACM.2021.19.1.28

Two Cases of Medical Device-Related Corynebacterium striatum Infection: A Meningitis and A Sepsis

Yeung Chul Mun, Miae Lee, Sholhui Park, Hae-Sun Chung, Eui Kyo Seo, Yeung Chul Mun, Miae Lee¹

^¹Departments of Laboratory Medicine, Ewha Womans University School of Medicine, Seoul, Korea

^²Departments of Neurosurgery, Ewha Womans University School of Medicine, Seoul, Korea

^³Departments of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea

Correspondence: Miae Lee, Department of Laboratory Medicine, Ewha Womans University School of Medicine, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea. (Tel) 82-2-2650-5222, (Fax) 82-2-2650-5091, (E-mail) miae@ewha.ac.kr

Received 10 January 2016 Revised 25 February 2016 Accepted 7 March 2016

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Corynebacterium striatum is a commonly isolated contaminant in the clinical microbiology. However, it can be an opportunistic pathogen in immunocompromised and even immunocompetent hosts. The increasing prevalence of C. striatum infection has been associated with immunosuppression and prosthetic devices. We report a case of meningitis with cerebrospinal fluid drainage and a case of catheter-related bloodstream infection caused by C. striatum. The isolates were identified as nondiphtherial Corynebacterium species by VITEK 2 (bioMérieux, France) anaerobe and Corynebacterium card. The final identification by 16S rRNA gene sequencing analysis was C. striatum with 99.7% identity and 99.6% identity with C. striatum ATCC 6940, respectively. Both strains were sensitive to vancomycin and gentamicin, but multi-drug-resistant to ciprofloxacin, penicillin, erythromycin and imipenem.

Keywords: Bloodstream infection, Corynebacterium striatum, Meningitis, 16S rRNA gene sequencing

References

1. Lee PP, Ferguson DA Jr, Sarubbi FA. Corynebacterium striatum: an underappreciated community and nosocomial pathogen. J Infect. 2005; 50:338–43.

2. Bowstead TT and Santiago SM. Pleuropulmonary infection due to Corynebacterium striatum. Br J Dis Chest. 1980; 74:198–200.

3. Boltin D, Katzir M, Bugoslavsky V, Yalashvili I, Brosh-Nissimov T, Fried M, et al. Corynebacterium striatum–a classic pathogen eluding diagnosis. Eur J Intern Med. 2009; 20:e49–52.

4. Renom F, Gomila M, Garau M, Gallegos MD, Guerrero D, Lalucat J, et al. Respiratory infection by Corynebacterium striatum: epidemiological and clinical determinants. New Microbes New Infect. 2014; 2:106–14.

5. Reece RM, Cunha CB, Rich JD. Corynebacterium minutissimum vascular graft infection: case report and review of 281 cases of prosthetic device-related Corynebacterium infection. Scand J Infect Dis. 2014; 46:609–16.

6. Schuurman T, de Boer RF, Kooistra-Smid AM, van Zwet AA. Prospective study of use of PCR amplification and sequencing of 16S ribosomal DNA from cerebrospinal fluid for diagnosis of bacterial meningitis in a clinical setting. J Clin Microbiol. 2004; 42:734–40.

7. Kim OS, Cho YJ, Lee K, Yoon SH, Kim M, Na H, et al. Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species. Int J Syst Evol Microbiol. 2012; 62:716–21.

8. Funke G, von Graevenitz A, Clarridge JE 3rd, Bernard KA. Clinical microbiology of coryneform bacteria. Clin Microbiol Rev. 1997; 10:125–59.

9. Choi HS, Kim JS, Jung ES, Kim AJ, Jung H, Park YS, et al. A case of postoperative intra-abdominal infection caused by Corynebacterium striatum. Korean J Med. 2012; 82:516–9.

10. Yoo G, Kim J, Uh Y, Lee HG, Hwang GY, Yoon KJ. Multidrug-resistant Corynebacterium striatum bacteremia: first case in Korea. Ann Lab Med. 2015; 35:472–3.

11. Yang HS, Kim YJ, Cho SY, Shin E, Lee HJ. Central venous catheter-related bloodstream infection by Corynebacterium striatum identified by 16S rRNA and rpoB gene sequencing. Ann Lab Med. 2015; 35:548–50.

12. Khamis A, Raoult D, La Scola B. rpoB gene sequencing for identification of Corynebacterium species. J Clin Microbiol. 2004; 42:3925–31.

13. Bernard K. The genus corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol. 2012; 50:3152–8.

14. Otsuka Y, Ohkusu K, Kawamura Y, Baba S, Ezaki T, Kimura S. Emergence of multidrug-resistant Corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with underlying diseases. Diagn Microbiol Infect Dis. 2006; 54:109–14.

15. Olender A. Mechanisms of antibiotic resistance in Corynebacterium spp. causing infections in people. In:. Pana M, editor. ed.Antibiotic resistant bacteria – A continuous challenge in the new millennium. 1st ed. InTech: 2012. p. 387–402.

Table 1.

Identification of the isolates

Isolate No.	Culture site	Phenotypic method (VITEK 2)	16S rRNA gene analysis
Strain 1.	CSF and drainage tip	Corynebacterium striatum	Corynebacterium striatum
Strain 2.	Catheter blood and peripheral blo	ood 1 ^st Corynebacterium amycolatum 2^nd Corynebacterium striatum	Corynebacterium striatum

Table 2.

Antimicrobial susceptibility test of the isolates

Antibiotics	MIC (μ g/mL)
	Strain 1	Strain 2	CLSI interpretive criteria
			S	I	R
Penicillin	＞32	＞32	≤1	2	≥4
Imipenem	＞32	＞32	≤4	8	≥16
Ciprofloxacin	＞32	＞32	≤1	2	≥4
Erythromycin	4	4	≤0.5	1	≥2
Gentamicin	0.06	4	≤4	8	≥16
Vancomycin	0.75	0.75	≤2

Abbreviations: MIC, minimal inhibitory concentration; CLSI, Clinical and Laboratory Standards Institute; S, susceptible; I, intermediate; R, resistant.

TOOLS

Similar articles