There are two major problems in the management of infected non-union of the tibia: how to treat the infection; and how to obtain bony union. The previous treatment as debridement and antibiotic therapy often failed. Multiple hospitalization, many operative procedures, and prolonged treatments with parenteral antibiotics cause not only functional disability but also economic hardship and loss of self-esteem. The authors reviewed a case of infected non-union of the tibia who has received 12 operations and prolonged intravenous antibiotic therapy. It is suggested that if appropriate drainage, complete excision of necrotic tissues and rigid fixation is provided, prolonged intravenous antibiotic therapy seems to be unnecessary.