Journal List > J Korean Breast Cancer Soc > v.7(3) > 1076730

J Korean Breast Cancer Soc. 2004 Sep;7(3):180-184. Korean.
Published online September 30, 2004.  https://doi.org/10.4048/jkbcs.2004.7.3.180
Copyright © 2004 Korean Breast Cancer Society
Axillary Lymph Node Metastasis in Patients of Ductal Carcinoma in Situ or Ductal Carcinoma in Situ with Microinvasion
Gil Soo Son, Tae Hyoung Kim, Jun Won Um, Jae Bock Lee, Jeoung Won Bae, and Bum Hwan Koo
Department of Surgery, Korea University College of Medicine, Seoul, Korea.
Received August 13, 2004; Accepted September 14, 2004.

Abstract

Purpose

The development of publicized screening methods for breast carcinoma detection has led to a marked increase in the discovery of ductal carcinoma in situ (DCIS) or DCIS with microinvasion (DCIS-MI). Axillary lymph node status has been believed to be not only an indicator of prognosis, but also a direction of adjuvant therapy. But the incidence of axillary metastasis in DCIS or DCIS-MI has diversely found in from 0% to 20%. This study was performed to analyze the incidence of axillary metastasis and the predictive factors associated with axillary lymph node metastasis in DCIS or DCIS-MI.

Methods

Patients with DCIS or DCIS-MI and axillary lymph node dissection from 1987 to 2004 were selected from Korea University Medical Center. We reviewed their medical records for age, palpability and size of the tumor, histolgic subtype, nuclear grade, hormone receptor status, and pathologic slides.

Results

Fifty two patients in DCIS and Thirty eight patients in DCIS-MI were included in the study. Axillary lymph node metastases were identified in 2 patients (3.8%) in DCIS and 4 patients (10.5%) in DCIS-MI. Tumor size and nuclear grade in DCIS had a borderline significance in association with microinvasion. We could not be able to find any predictive factor associated with axillary lymph node metastasis in DCIS and DCIS-MI.

Conclusion

Axillary lymph node metastasis in DCIS or DCIS-MI appeared to be not low and there was no predictive factor associated with axillary lymph node metastasis in DCIS and DCIS-MI. But DCIS patients with large tumor size and poor nuclear grade have the high possibility associated with microinvasion, therefore, in that cases, there is a need to consider the possibility of axillary metastasis.

Keywords: Lymph node metastasis; Ductal carcinoma in situ; Microinvasion; Breast