Journal List > J Korean Breast Cancer Soc > v.6(3) > 1076691

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Kim, Lee, Moon, Choi, Sung, Choi, and Suh: The Efficacy of Sentinel Node Biopsy Using Subareolar Injection of Radioactive Material in Breast Cancer
Original Article
Journal of Korean Breast Cancer Society

Journal of Korean Breast Cancer Society 2003; 6(3): 180-185.

Published online: 30 September 2003

DOI: https://doi.org/10.4048/jkbcs.2003.6.3.180

The Efficacy of Sentinel Node Biopsy Using Subareolar Injection of Radioactive Material in Breast Cancer

Hyun Ah Kim, Jae Hyuk Lee, Byung In Moon, Kum Ja Choi, Soon Hee Sung1, Hye Young Choi2, Hyun Suk Suh3

Department of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.

1Department of Pathology, College of Medicine, Ewha Womans University, Seoul, Korea.

2Department of Radiology, College of Medicine, Ewha Womans University, Seoul, Korea.

3Department of Radiation Oncology, College of Medicine, Ewha Womans University, Seoul, Korea.

mbit@ewha.ac.kr

Received 4 August 2003       Accepted 22 September 2003

Copyright © 2003 Korean Breast Cancer Society

Abstract

Purpose

This study was designed to evaluate the feasibility of sentinel node biopsy (SNB) using subareolar injection of radioactive material in breast cancer.

Methods

The prospective study was performed of 112 breast cancers (T1 or T2 stages) at Ewha Womans University Mok-Dong Hospital from February 2001 to June 2003. Patients underwent lymphoscintigraphy using 99mTc sulfur colloid. The feasibility of SNB was assessed through comparison with simultaneous axillary node dissection.

Results

All patients were women, and the median age was 46 years. Internal mammary sentinel lymph node was identified in 2 cases (1.8%). The first node was appeared on lymphoscintigraphy around at 10.7 minutes after subareolar injection. Sentinel nodes could be identified in 111 (99.1%) among 112 patients with a gamma probe. The mean number of harvested sentinel nodes were 3.3 and metastasis was noted 80 of 368 nodes (21.7%). False negative rate was 4.1%.

Conclusion

SNB using subareolar injection of radioactive material could be a alternative method to replace axillary node dissection in T1 or T2 breast cancers, especially in case of clinical node negative patients.

Keywords: Sentinel node, Subareolar injection, Lymphoscintigraphy

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