Oxaliplatin-Induced Peripheral Neuropathy and Quality of Life in Patients with Digestive System Cancer

Hye Young Kim

doi:10.7475/kjan.2016.28.3.343

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Kim: Oxaliplatin-Induced Peripheral Neuropathy and Quality of Life in Patients with Digestive System Cancer

Original Article

Korean Journal of Adult Nursing 2016; 28(3): 343-353.

Published online: 30 June 2016

DOI: https://doi.org/10.7475/kjan.2016.28.3.343

Oxaliplatin-Induced Peripheral Neuropathy and Quality of Life in Patients with Digestive System Cancer

Hye Young Kim

College of Nursing, Research Institute of Nursing Science, Chonbuk National University, Jeonju, Korea.

Corresponding author: Kim, Hye Young. College of Nursing, Research Institute of Nursing Science, Chonbuk National University, 567 Baekje-daero, deokjin-gu, Jeonju 54896, Korea. Tel: +82-63-270-4618, Fax: +82-82-63-270-3127, tcellkim@jbnu.ac.kr

Received 29 March 2016 Revised 20 May 2016 Accepted 20 June 2016

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study aimed to identify the levels of oxaliplatin-induced peripheral neuropathy (OXLIPN) and the quality of life (QOL) related to OXLIPN in patients with digestive system cancer.

Methods

A total of 83 patients with chemotherapy-induced peripheral neuropathy (CIPN)-related symptoms participated in this study. Data were collected through self-reported questionnaire which were constructed to include general and clinical characteristics, EORTC QLQ-C30, Patient Neurotoxicity Questionnaire (PNQ), and EORTC QLQ-CIPN20.

Results

The average scores of OXLIPN upper and lower extremity scale were 30.01 and 29.16, respectively. The average scores of PNQ sensory and motor scale were 2.11 and 1.70, respectively. The mean score of the QLQ-C30 global health status was 54.85, and the range of mean score of the functional and symptom subdomains was 34.85~73.29 and 17.67~53.54, respectively. The CIPN-related symptoms positively correlated with the global health status scale and all subdomains of functional scale, respectively and negatively correlated with fatigue, pain, dyspnea, insomnia, and financial problem subdomains of the symptom scale, respectively.

Conclusion

Oncology nurses should pay attention and provide remedies for CIPN symptoms reported by their patients. Nursing interventions should be developed for patients with digestive system cancer to alleviate CIPN and enhance their QOL.

Keywords: Quality of life, Chemotherapy, Peripheral neuropathies, Digestive system neoplasms

Figures and Tables

Table 1

Mean Differences in OXLIPN according to General and Clinical Characteristics (N=83)

OXLIPN=oxaliplatin-induced peripheral neuropathy; 16-item QLQ-CIPN20=16-item quality of life questionnaire-chemotherapy-induced peripheral neuropathy; PNQ=patient neurotoxicity questionnaires; ECOG PS=Eastern Cooperative Oncology Group Performance Status.

Table 2

Participants Reporting “quite a bit” or “very much” on 16-item QLQ-CIPN20 and Neurotoxic Events graded by PNQ (N=83)

16-item QLQ-CIPN20=16-item quality of life questionnaire-chemotherapy-induced peripheral neuropathy; PNQ=patient neurotoxicity questionnaires.

Table 3

Participants' Level of 16-item QLQ-CIPN20, PNQ and EORTC QLQ-C30 (N=83)

16-item QLQ-CIPN20=16-item quality of life questionnaire-chemotherapy-induced peripheral neuropathy;

EORTC QLQ-C30=European Organization for the Research and Treatment of Cancer quality of life questionnaire core 30 items;

PNQ=patient neurotoxicity questionnaires.

Table 4

Correlation among the 16-item QLQ-CIPN20 Subscales, PNQ Subscales, and Health-related QOL (N=83)

16-item QLQ-CIPN20=16-item quality of life questionnaire-chemotherapy-induced peripheral neuropathy; EORTC QLQ-C30=European

Organization for the Research and Treatment of Cancer quality of life questionnaire core 30 items; PNQ=patient neurotoxicity questionnaires.

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