Journal List > J Korean Soc Spine Surg > v.17(1) > 1075917

Shin, Ahn, Chung, and Lee: Epidural Granulocytic Sarcoma presenting as Thoracic Spinal Cord Compression - Case Report -

Abstract

Study Design

A case report

Objectives

This case report presents a patient with thoracic spinal cord compression, who had been on regular follow-up after being diagnosed with myelodysplastic syndrome.

Summary of Literature Review

A granulocytic sarcoma is a rare tumor that occurs in the extramedullary sites, forming a localized lesion with a predilection in the orbit, sinus and periosteum. It rarely involves the central nervous system, particularly spinal cord.

Material and Methods

For myelodysplastic syndrome, the patient underwent a bone marrow transplant for the condition. He was placed on conservative treatment until he developed sudden abdominal pain. He was admitted to our hospital through the emergency department. On the 2nd hospital day he complained of increasing weakness in his lower extremities. He underwent an emergency decompression of the spinal cord and his motor weakness completely disappeared.

Results

No signs of recurrence were found on the follow up performed at 2 years and 6 months.

Conclusion

Epidural granulocytic sarcoma is rare but can be treated successfully.

REFERENCES

1.Shiozawa Y., Kiyokawa N., Saito M., Fujimoto J., Hata J., Yamashiro Y. Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review. Eur J Pediatr. 2005. 164:616–20.
crossref
2.Sandhu GS., Ghufoor K., Gonzalez-Garcia J., Elexpuru-Camiruaga JA. Granulocytic sarcoma presenting as cauda equina syndrome. Clin Neurol Neurosurg. 1998. 100:205–8.
crossref
3.Balleari E., Panarello S., Capello E, et al. Granulocytic sarcoma: an unusual cause of spinal cord compression. International Journal of Clinical Oncology. 2007. 12:234–7.
crossref
4.Choi WY., IS Kim., Choi IY, et al. Granulocytic Sarcoma as a Presenting Spinal Cord Compression. Korean J Internal Medicine. 1992. 42:549–54.
5.Landis DM., Aboulafia DM. Granulocytic Sarcoma: An Unusual Complication of Aleukemic Myeloid Leukemia Causing Spinal Cord Compression. A Case Report and Literature Review. Leukemia and Lymphoma. 2003. 44:1753–60.
crossref
6.Mostafavi H., Lennarson PJ., Traynelis VC. Granulocytic sarcoma of the spine. Neurosurgery. 2000. 46:78–83.
crossref
7.Brunning RD., Matutes E., Flandrin G. Acute myeloid leukemia not otherwise specified. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (WHO). Lyon, France: IARC Press;2001.
crossref

Fig. 1.
Magnetic resonance imaging showing epidural tumor compressing thoracic spinal cord. (A) T-1 weighted saggital and axial images showing epidural tumor compressing thoracic spinal cord. (B) T-2 weighted saggital and axial images showing epidural tumor compressing thoracic spinal cord T1 & T2.
jkss-17-33f1.tif
Fig. 2.
Immediate postoperative x-rays after total laminectomy and posterior instrumentation. (A) AP view. (B) Lateral view.
jkss-17-33f2.tif
Fig. 3.
Gross and microscopic photographs. Infiltrate consists of atypical round cells suggestive of myeloid origin, with cells varying in size and morphology showing vesicular nuclei, prominent nucleoli, and a few mitotic figures[H&E stain, original magnification ×400]
jkss-17-33f3.tif
Fig. 4.
Immunohistochemical staining showed expression (brown) of myeloperoxidase, C-kit, and TdT. [original magnification ×400]
jkss-17-33f4.tif
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