Antifungal Resistance in Yeasts and Filamentous Fungi

Jong Hee Shin

doi:10.3947/ic.2009.41.2.65

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Shin: Antifungal Resistance in Yeasts and Filamentous Fungi

Review Article

Infection and Chemotherapy

Infection and Chemotherapy 2009; 41(2): 65-71.

Published online: 30 April 2009

DOI: https://doi.org/10.3947/ic.2009.41.2.65

Antifungal Resistance in Yeasts and Filamentous Fungi

Jong Hee Shin, M.D.

Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.

Correspondence: Jong Hee Shin, M.D. Department of Laboratory Medicine, Chonnam National University Medical School, 671 Jaebongro, Dong-gu, Gwangju 501-757, Korea. Tel: +82-62-220-5342, Fax: +82-62-224-2518, shinjh@chonnam.ac.kr

Received 4 March 2009

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The incidence of invasive fungal infection has increased worldwide along with the increasing population of high risk patients. Recently developed antifungal agents, such as second-generation triazoles and echinocandins, provide the potential to improve therapeutic options against invasive fungal infections. However, treatment of invasive fungal infections has been hampered by both intrinsic and acquired resistance to antifungal agents among many fungal pathogens. A better understanding of the clinical impact of antifungal resistance is important for selecting the proper antifungal agent in patients with systemic fungal infections. This article reviews the current situation with regard to intrinsic and acquired resistance of clinically significant yeasts and filamentous fungi against currently available antifungal agents.

Keywords: Antifungal drug resistance, Azoles, Echinocandins, Amphotericin B, Filamentous fungi

Figures and Tables

Table 1

General patterns of In vitro Antifungal susceptibility of Yeasts and Major Filamentous Fungi^*

Abbreviations : Flu, fluconazole; Itra, itraconazole; Vori, voriconazole; Pos, posaconazole; AmB, amphotericin B; Candins, echinocandins; S, reliable activity with occasional resistance; S-I, moderate activity but resistance is noted; R-I, occasional activity; R, no meaningful activity.

^*Adopted from references (1-4).

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