A Case of Multidrug-resistant Acinetobacter baumannii Ventriculitis Successfully Treated with Intrathecal Colistimethate

Yu-ah Hong; Jin-Hong Yoo; Jin-Jin Kim; Eun-Yeong Mo; Gun-Hee Ahn; Hee-Kyoung Jeong; Jin-Seok Kim; Hyun-Jeong Lee; Mi-Hyang Jung; Seung-Bae Yoon

doi:10.3947/ic.2009.41.4.240

Journal List > Infect Chemother > v.41(4) > 1075471

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Hong, Yoo, Kim, Mo, Ahn, Jeong, Kim, Lee, Jung, and Yoon: A Case of Multidrug-resistant Acinetobacter baumannii Ventriculitis Successfully Treated with Intrathecal Colistimethate

Case Report

Infection and Chemotherapy

Infection and Chemotherapy 2009; 41(4): 240-244.

Published online: 31 August 2009

DOI: https://doi.org/10.3947/ic.2009.41.4.240

A Case of Multidrug-resistant Acinetobacter baumannii Ventriculitis Successfully Treated with Intrathecal Colistimethate

Yu-ah Hong, M.D., Jin-Hong Yoo, M.D., Jin-Jin Kim, M.D., Eun-Yeong Mo, M.D., Gun-Hee Ahn, M.D., Hee-Kyoung Jeong, M.D., Jin-Seok Kim, M.D., Hyun-Jeong Lee, M.D., Mi-Hyang Jung, M.D., Seung-Bae Yoon, M.D.

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Corresponding author: Jin-Hong Yoo, M.D. Department of Internal Medicine, Division of Infectious diseases, Holy Family Hospital, 2 Sosa-Dong, Wonmi-gu, Bucheon-city, Gyunggi-do 420-717, Korea. Tel: +82-32-340-2114, Fax: +82-32-340-2669, jhyoo@catholic.ac.kr

Received 9 March 2009 Accepted 1 May 2009

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

Keywords: Acinetobacter, Colistimethate sodium (colistin), CNS infection

Figures and Tables

Fig. 1

Gram stain on CSF showed numerous gram negative cocobacilli that were identified as Acinetobacter baumannii (Cerebrospinal fluid, H&E stain, ×1,000).

Table 1

Summary of Antibiotic Treatment and Laboratory Data in a Patient with Multidrug-resistant Acinetobacter baumannii Ventriculitis

Abbreviations: CSF, cerebrospinal fluid; PMN, polymorphonuclear cells; Lym, lymphocytes; IV, intravenous

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