Disseminated Mycobacterium avium Complex Infection in a Patient with Acquired Immunodeficiency Syndrome

Sul Hee Yi; Jae Huk Choi; Moon Han Choi; Dong Won Shin; Jong Hyo Choi; Tae Young Kim; Min Hyok Jeon; Eun Suk Koh; Eun Ju Choo

doi:10.3947/ic.2008.40.5.297

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Yi, Choi, Choi, Shin, Choi, Kim, Jeon, Koh, and Choo: Disseminated Mycobacterium avium Complex Infection in a Patient with Acquired Immunodeficiency Syndrome

Case Report

Infection and Chemotherapy

Infection and Chemotherapy 2008; 40(5): 297-300.

Published online: 25 October 2008

DOI: https://doi.org/10.3947/ic.2008.40.5.297

Disseminated Mycobacterium avium Complex Infection in a Patient with Acquired Immunodeficiency Syndrome

Sul Hee Yi, M.D.¹, Jae Huk Choi, M.D.¹, Moon Han Choi, M.D.¹, Dong Won Shin, M.D.¹, Jong Hyo Choi, M.D.¹, Tae Young Kim, M.D.¹, Min Hyok Jeon, M.D.¹, Eun Suk Koh, M.D.², Eun Ju Choo, M.D.¹

¹Division of infectious Disease, Soonchunhyang University College of Medicine, Bucheon, Korea.

²Division of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea.

Correspondence: Eun Ju Choo, M.D. Division of Infectious Disease, Department of Internal Medicine, Soonchunhyang University College of Medicine, 1174, Jung-dong, Gyeonggi 420-020, Korea. Tel: +82-32-621-5202, Fax: +82-32-621-5016, mdchoo@schbc.ac.kr

Received 23 June 2008 Accepted 22 August 2008

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nontuberculous Mycobacteria, especially Mycobacterium avium complex (MAC) infection is a common opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). In patients with AIDS, MAC infection more frequently presents as disseminated form rather than localized infection. Disseminated MAC infection is associated with a high mortality rate in patient with AIDS. We report a case of disseminated MAC infection in an AIDS patient involving bone marrow, mediastinal lymph node and lung.

Keywords: Mycobacterium avium complex, AIDS

Figures and Tables

Figure 1

Brownish colored macules or patches with scales in right lower arm. The skin lesions were on the entire body accompanied by pruritus. The largest lesion was 1.5 by 1 cm sized.

Figure 2A

Enhanced chest CT shows multiple mediastinal lymphadenopathy.

Figure 2B

PET CT shows increased uptake in multiple mediastinal lymph nodes.

Figure 3A

Mediastinal lymph node biopsy shows chronic granulomatous inflammation (×100).

Figure 3B

Numerous acid-fast bacteria were noted on Ziehl-Neelsen stain in mediastinal lymph node biopsy (×1,000).

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