Cardiac myxomas are the most common type of primary cardiac tumor. Approximately 86% of myxoma occur in the left atrium, and over 90% are solitary. Most myxoma are gelatinous and solid, although central hemorrhage or infarction may occur in some case. Rarely is the myxoma calcified. We experienced the case of a 52-year-old man transthoracic echocardiography revealed central echolucency within large mass. At operation, a globular, smooth surfaced mass was found attached to the interatrial septum of left atrium. The cut-surface shows central cystic degeneration within extensive patch hemorrhage and multiple small cysts.