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Abstract
Background
Perindopril. a new second-generation angiotensin converting enzyme inhinbitor was administered in essential hypertensive patients in order to observe the clinical effects.
Method
The changes of blood pressure, heart rate, clinical laboratory examinations, side effects, electrocardiogram, echocardiographic left ventricular mass, and left ventricular diastolic function were evaluated before and after 4–8mg of perindopril for 12 weeks administration in 20 essential hypertensive patients(male 4, female 16; mean age 57 ± 12 years).
Results
1) The average of blood pressure of 20 subjects were systolic 172.5 ± 17.4mmHg and diastolic 106.4 ± 7.7mmHg before treatment which were lowered to 142.8 ± 16.0mmHg and 88.6 ± 8.6mmHg respectively ofter 12 weeks(P<0.05). There was no significant reduction in heart rate.
2) The average of left ventricular mass before treatment was 287.5 ± 61g. which was lowered to 251.3 ± 39.7g. But there was no significant difference in left ventricular mass before and after treatment(P>0.05). There was no significant difference in left ventricular diastolic dysfunction before and after treatment.
3) Side effects were 2 cases of mild dry cough and 2 headache.
References
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Table 1.
고혈압 치료전후의 혈압 및 심박수의 변화
| 치료전 | 치료후 | P 값 | |
|---|---|---|---|
| 수축기(mmHg) | 172.5 ± 17.4 | 142.8 ± 16.0 | <0.05 |
| 확장기 (mmHg) | 106.4 ± 7.7 | 88.6 ± 8.6 | <0.05 |
| 심박수(회/분) | 82.7 ± 9.3 | 79 ± 7.8 | NS∗ |
Table 2.
고혈압 치료전후 좌심실의 형태학적 변화
LVIDd: left ventricle end-diastolic internal dimension, LVIDs: left ventricle end-systolic internal dimension, IVSTd: end-diastolic interventricular septal thickness, PWTd: end-diastolic posterior wall thickness, LVM: left ventricle mass, PSWS: peak sytolic wall stress, EF: ejection fraction, Vcf: mean circumferential fiber shortening
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