LV Mass and Left Ventricular Systolic Function After Antihypertensive Therapy

Eui Ryong Cheong; Shung Chull Chae; Jae Eun Jun; Wee Hyun Park

doi:10.3803/jkes.1994.2.2.187

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Cheong, Chae, Jun, and Park: LV Mass and Left Ventricular Systolic Function After Antihypertensive Therapy

Original Article

J Korean Soc Echocardiogr 1994;2(2):187-191.

Published online: 18 February 1994

DOI: https://doi.org/10.3803/jkes.1994.2.2.187

LV Mass and Left Ventricular Systolic Function After Antihypertensive Therapy

Eui Ryong Cheong, M.D., Shung Chull Chae, M.D., Jae Eun Jun, M.D., Wee Hyun Park, M.D.

Department of Medicine, School of Medicine, Kyungpook National University, Taegu, Korea

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Left ventricular hypertrophy is one of independent predictors of cardiovascular mortality and morbidity. Many studies have shown that the left ventricular hypertrophy could be regressed with the anti-hypertensive therapy. This study was designed to clarify that the left ventricular hypertrophy could be regressed with the anti-hypertensive therapy.

Method

Thirty six patients with essential hypertension were studied and patients with coronary heart disease, valvular heart disease, or secondary hypertension were excluded. Echocardiographic measurements were obtained at the start of anti-hypertensive therapy and followed up after 6 months of therapy or later. Used anti-hypertensive agents were calcium channel blockers. Angiotensin converting enzyme inhibitors, beta blockers or diuretics, alone or combined.

Result

The results can be summaried as follows. 1) Mean initial blood pressure was 158/100 mmHg and significantly fell to 135/83 after anti-hypertensive therapy. 2) Mean LV mass was also markedly reduced from 302 grams to 255 grams. 3) Fractional shortening and ejection fraction were increased from 33 % to 36% and from 68% to 73% respectively.

Conclusion

These results suggest that antihypertensive therapy could reduce left ventricular hypertrophy and improve left ventricular systolic function.

Keywords: Hypertension, Left ventricular hypertrophy.

References

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Table 1.

Characteristics of subjects

Age(range)	55.1 ± 11.1 (29–84)
Sex(m/f)	16/20
BSA(m²)	1.68 ± 0.13
BP(initial)	158 ± 34.7 / 100 ± 21.6
BP^∗(follow-up)	135 ± 14.7/ 83 ± 10.2
Follow-up duration(mo)	30 ± 22

Data are expressed as mean± SD.

^∗ p<0.01

Table 2.

Echocardiographic measurements(cm)

	Initial	Follow-up	% change
LVIDd	5.00 ± 0.72	4.80 ± 0.65^∗∗	–2 ± 11
LVIDs	3.37 ± 0.60	3.13 ± 0.63^∗∗	–6 ± 16
SWT	1.34 ± 0.28	1.27 ± 0.29^∗	–8 ± 15
LVPWT	1.06 ± 0.13	0.98 ± 0.12^∗	–6 ± 12
LAD	4.01 ± 0.66	3.94 ± 0.68	–1 ± 12

^∗ p<0.05,

^∗∗ p<0.01

Data are expressed as mean± SD.

Table 3.

LV mass and other echocardiographic parameters

	Initial	Follow-up	% change
LV mass(gm)	302 ± 78	255 ± 59.0^∗∗	–13 ± 15
LV mass index(g/m²)	180 ± 52.8	153 ± 37.4^∗	–12 ± 17
FS(%)	33 ± 8	36 ± 8	9 ± 5
EF(%)	68 ± 13	73 ± 10	7 ± 6

^∗ p<0.01,

^∗∗ p<0.001

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