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Choi and Lee: Study on the Change of Serum Lipids
Original Article
Korean Circulation Journal

Korean Circulation Journal 1975; 5(1): 1-17.

Published online: 30 June 1975

DOI: https://doi.org/10.4070/kcj.1975.5.1.1

Study on the Change of Serum Lipids

Yun Shik Choi, M.D., Sung Ho Lee, M.D.

Copyright © 1975 The Korean Society of Circulation

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To observe the effect of serious illness, surgical trauma, body weight, and clofibrate on serum lipids, the serum levels of cholesterol and triglyceride with lipoprotein patterns by electrophoresis on cellulose acetate membrane were studied in 30 normal persons, 18 patients with coronary heart disease, 26 patients with cerebral thrombosis, and 7 surgical patients.
The results obtained were as follows;
1. The values of serum cholesterol and triglyceride in cerebral thrombosis and coronary heart disease were markedly higher than those of control, and the optic dinsities of each serum lipoprotein fractions were also increased significantly.
2. Serum lipoprotein type IIa and IIb were more frequently observed than type IV in cerebral thrombosis and coronary heart disease.
3. The change of serum cholesterol and triglyceride related moderately to relative body weight in normal persons.
4. The decrease in serum cholesterol occured on the 1st day following surgery, and recovered to 97.8% of the preoperation level on the 7th day. The serum triglyceride started to increase on the 3rd day following surgery, and reached to 115.1% of the preoperation level on the 7th day.
5. After attack of cerebrovascular accident the serum cholesterol and triglyceride level increased slowly to the 122.1% and 133.1% of the each lst day level on the 7th day.
6. The serum lipid lowering effect of clofibrate was most conspicuous in the hypertriglyceridemic patients, especially during lst and 2nd week after medication, and mixed hyperlipidemic patients responded moderately. But pure hypercholesterolemic patients resisted completely. The optic densities of each serum lipoprotein fraction were also decreased in drug responded groups.

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