Abstract
Authors observed the antihypertensive effect of debriscquin sulfate in 35 cases cf essential hypertension and following results were obtained.
1) Results of short term control of blood pressure with debrisquin in 35 hypertensive patients revealed good control in 74.3%, fair in 14. 3%, peer in 5.7 % and failure in 5.7% cf cases. Significant reduction of blood pressure was achieved in 7 of 9 cases cf hypertension with addition of hydrochlcrthiazide to debrisoquin.
2) During long term therapy with debriscquin (duration of average 3.9 months), good control cases were slightly reduced(good in 58.6%, fair in 24.1%’ poor in 6.9%, failure in 1C.3%). Eut average effective dose of debriicquin was not increased significantly.
3) Antihypertensive effect of debriscquin was slightly reduced in the cases of severe hypertension, hypertension of over 10 years duration and complication of cerebrovascular accident.
4) The side effects during treatment with debriscquin were dizziness in 31.4%, headache in 11, 496, dry mouth, blurred vision, gneral weakness, insomnia in Q. 6% respectively. There were no side effects in 48.696 of cases.
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Table 1.
Age (yrs) | Male | Female | Total(%) |
---|---|---|---|
30~39 | 6 | 2 | 8 (22.9) |
40~49 | 6 | 3 | 9 (25.7) |
50~59 | 6 | 8 | 14 (40.0) |
60~69 | 3 | 1 | 4 (11.4) |
Total | 21 (60.0) | 14 (40.0) | 35 (100.0) |
Table 2.
Table 4.
Table 7.
Severity of hypertension | No. of case | Results of treatment | |||
---|---|---|---|---|---|
Good | Fair | Poor | Failure | ||
Mild | 12 | 10(83.3) | 2(16.7) | 0 (0) | 0 (0) |
Moderaae | 18 | 15(83.3) | 1 (5.6) | 2(11.1) | 0 (0) |
Severe | 5 | 1(20.0) | 2(40.0) | 0 (0) | 2(40.0) |